Effect of proton pump inhibitors on sympathetic hyperinnervation in infarcted rats: Role of magnesium

PloS One
Tsung-Ming LeeShinn-Zong Lin

Abstract

The long-term use of proton pump inhibitors (PPIs) has been shown to increase the risk of cardiovascular mortality, however the molecular mechanisms are unknown. Superoxide has been implicated in the regulation of nerve growth factor (NGF), a mediator of sympathetic innervation. The purpose of this study was to determine whether PPIs increase ventricular arrhythmias through magnesium-mediated superoxide production in infarcted rats. Male Wistar rats were randomly assigned to receive vehicle, omeprazole, omeprazole + magnesium sulfate, or famotidine treatment for 4 weeks starting 24 hours after the induction of myocardial infarction by ligating the coronary artery. Increased myocardial superoxide and nitrotyrosine levels were noted post-infarction, in addition to a significant upregulation of NGF expression on mRNA and protein levels. Sympathetic hyperinnervation after infarction was confirmed by measuring myocardial norepinephrine and immunofluorescent analysis. Compared with the vehicle, omeprazole-treated infarcted rats had significantly reduced myocardial magnesium content, increased oxidant production, and increased sympathetic innervation, which in turn increased ventricular arrhythmias. These effects were prevented by the...Continue Reading

References

Jan 31, 1992·Biochemical and Biophysical Research Communications·N MasumotoO Tanizawa
Mar 11, 1991·Journal of the American College of Cardiology·R A ReinhartR G Haas
May 1, 1994·Circulation Research·W B WeglickiT M Phillips
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·A M ColangeloI Mocchetti
Jan 15, 2000·Journal of Clinical Gastroenterology·C W Howden
Apr 3, 2001·Digestive Diseases and Sciences·G Sener-MuratoğluG Ayanoğlu-Dülger
Feb 8, 2003·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Andrzej KuzniarMarta Stryjecka-Zimmer
Aug 19, 1964·Biochimica Et Biophysica Acta·M P SPARROW, B M JOHNSTONE
Nov 2, 2005·Biochemical and Biophysical Research Communications·Karen Perez-de-ArceFederico Leighton
Feb 24, 2006·British Journal of Pharmacology·Péter Ferdinandy
Dec 6, 2006·Free Radical Biology & Medicine·Mariana PeharLuis Barbeito
Mar 29, 2008·Journal of the American College of Cardiology·Tsung-Ming LeeNen-Chung Chang
Apr 7, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Chih-Sen KangTsung-Ming Lee
Aug 22, 2009·Cardiovascular Research·Tsung-Ming LeeNen-Chung Chang
Nov 19, 2009·Annals of Internal Medicine·Maarten A C BroerenA Warmold L van den Wall Bake
Jun 2, 2011·Free Radical Biology & Medicine·Koichi Sugamura, John F Keaney
Mar 30, 2013·Kidney International·Mark A Perazella
Apr 27, 2013·Experimental & Translational Stroke Medicine·Thomas WestermaierRalf-Ingo Ernestus
Jul 13, 2013·American Journal of Therapeutics·Sunyong KimDae Ryong Kang
Sep 17, 2014·Free Radical Biology & Medicine·Tsung-Ming LeeNen-Chung Chang
May 15, 2015·Magnesium Research : Official Organ of the International Society for the Development of Research on Magnesium·Tahereh EshraghiSeyyed Mohammad Tavangar
May 12, 2016·Circulation Research·Gautham YepuriJohn P Cooke
Nov 21, 2016·Pflügers Archiv : European journal of physiology·Narongrit ThongonMatthana Thongma

❮ Previous
Next ❯

Citations

Oct 30, 2021·European Journal of Clinical Pharmacology·Bhargavi V DesaiBhavin A Vyas

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Software Mentioned

Image Pro Plus
SPSS

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.