May 1, 1975

Effect of psychotropic and anticonvulsive preparations on transport ATPase in the renal tubules of the guinea pig

Farmakologiia i toksikologiia
E F LavretskaiaI M Raĭkhman


The effect of 4 groups of medicamentous agents, viz. neoruleptics, tricyclic antidepressants, somnifacients and antiepileptics - on the activity of the transport ATPase and p-nitrophenylphosphatase from the renal tubules of the guinea pig was studied. Used in high concentrations neuroleptics suppress almost completely the activity of the enzyme, but in small doses influence but little that of the p-nitrophenylphosphatase. The butyrophenone derivatives have a mild effect upon the activity of the p-nitrophenylphosphatase and in low concentrations they stimulate it. The effect of tricyclic antidepressants closely approaches the one produced by neuroleptics-phenothiazines. Lithium carbonate leaves the enzyme intact. Barbiturates and antiepileptic agents inhibit but feebly these enzymes.

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Mentioned in this Paper

Antipsychotic Effect
Renal Tubule Structure
DNA-dependent ATPase
Nitrophenyl Phosphatase
Dose-Response Relationship, Drug
Enzyme Repression
Enzyme Activation

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