Effect of pulmonary artery angioplasty on exercise function after repair of tetralogy of Fallot

American Heart Journal
Nicole J SuttonJ Rhodes

Abstract

The slope of the minute ventilation versus CO2 production relationship (VE/VCO2 slope) is an index of gas exchange efficiency during exercise. In patients with repaired tetralogy of Fallot (rTOF), it correlates negatively with exercise capacity and is one of the best predictors of peak oxygen consumption (VO2). In these patients, the magnitude of the VE/VCO2 slope is related to the severity of pulmonary blood flow maldistribution (PBFM). The purpose of this study was to determine whether, in patients with rTOF, improvements in PBFM after a successful balloon angioplasty procedure (BAP) result in improvements in peak VO2 and gas exchange during exercise. Seventeen patients with rTOF and residual pulmonary artery stenoses referred for BAP were recruited. Exercise tests were performed and PBFM determined before and after BAP. Nine patients (group 1) had a successful BAP (ie, improvement of >5 percentage points in PBFM); 8 did not (group 2). Patients in group 1 had significantly greater improvements in VE/VCO2 slope, peak VO2, and peak oxygen pulse (an index of forward stroke volume at peak exercise) than did patients in group 2. A significant correlation existed between the improvement in PBFM and the decline in the VE/VCO2 slope ...Continue Reading

References

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Citations

Oct 24, 2009·Cardiology in the Young·I Ricardo Argueta-MoralesWilliam M DeCampli
Nov 28, 2013·Heart Failure Clinics·Jonathan Buber, J Rhodes
Aug 10, 2013·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Laura Mercer-RosaSteven M Kawut
Sep 22, 2009·The American Journal of Cardiology·Alessandro GiardiniGraham Derrick
May 3, 2011·The American Journal of Cardiology·Alaina K KippsJ Rhodes
Jun 29, 2015·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Shahryar M ChowdhuryGirish S Shirali
Jun 13, 2015·Disease Markers·Paloma Lopes Francisco ParazziJose Dirceu Ribeiro
Jun 7, 2011·American Heart Journal·Alessandro GiardiniGraham Derrick
Jan 27, 2017·Children·Paolo T PianosiHan C G Kemper
Nov 10, 2010·Circulation·J RhodesKathy J Jenkins
Jul 24, 2013·Circulation·Gerald F FletcherAmerican Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee of the Council on Clinical Cardiology,
Oct 12, 2013·The American Journal of Case Reports·Massimo Bolognesi, Diletta Bolognesi
Sep 19, 2019·Pediatric Cardiology·Jyothsna Akam-VenkataSanjeev Aggarwal
Dec 19, 2018·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Tarek AlsaiedRahul H Rathod
Feb 22, 2020·Trends in Cardiovascular Medicine·Gurumurthy HiremathVarun Aggarwal

Related Concepts

Teens
Arteriography
Angioplasty, Balloon
Blood Gas Analysis
Cardiopulmonary Exercise Test
Cardiac Surgery Procedures
Oxygen Consumption
Probability
Pulmonary Gas Exchange
Pulmonary Stenosis

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