Effect of pulmonary artery angioplasty on exercise function after repair of tetralogy of Fallot

American Heart Journal
Nicole J SuttonJ Rhodes


The slope of the minute ventilation versus CO2 production relationship (VE/VCO2 slope) is an index of gas exchange efficiency during exercise. In patients with repaired tetralogy of Fallot (rTOF), it correlates negatively with exercise capacity and is one of the best predictors of peak oxygen consumption (VO2). In these patients, the magnitude of the VE/VCO2 slope is related to the severity of pulmonary blood flow maldistribution (PBFM). The purpose of this study was to determine whether, in patients with rTOF, improvements in PBFM after a successful balloon angioplasty procedure (BAP) result in improvements in peak VO2 and gas exchange during exercise. Seventeen patients with rTOF and residual pulmonary artery stenoses referred for BAP were recruited. Exercise tests were performed and PBFM determined before and after BAP. Nine patients (group 1) had a successful BAP (ie, improvement of >5 percentage points in PBFM); 8 did not (group 2). Patients in group 1 had significantly greater improvements in VE/VCO2 slope, peak VO2, and peak oxygen pulse (an index of forward stroke volume at peak exercise) than did patients in group 2. A significant correlation existed between the improvement in PBFM and the decline in the VE/VCO2 slope ...Continue Reading


Jan 1, 1978·The American Journal of Cardiology·G R CummingL Hastman
Apr 1, 1990·Journal of the American College of Cardiology·A RothmanJ E Lock
May 1, 1995·British Heart Journal·A L ClarkA N Redington
Jun 1, 1997·Journal of the American College of Cardiology·T P ChuaA J Coats
May 12, 2007·The American Journal of Cardiology·Alessandro GiardiniFernando Maria Picchio


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May 3, 2011·The American Journal of Cardiology·Alaina K KippsJ Rhodes
Jun 29, 2015·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Shahryar M ChowdhuryGirish S Shirali
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Jun 7, 2011·American Heart Journal·Alessandro GiardiniGraham Derrick
Jan 27, 2017·Children·Paolo T PianosiHan C G Kemper
Nov 10, 2010·Circulation·J RhodesKathy J Jenkins
Jul 24, 2013·Circulation·Gerald F FletcherAmerican Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee of the Council on Clinical Cardiology,
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Angioplasty, Balloon
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