Effect of pulsatility and hemodynamic power on recovery of renal function

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
H KonishiRobert L Kormos

Abstract

Circulatory assist devices are used to treat patients awaiting cardiac transplantation to preserve life as well as to permit recovery of end-organ function. The efficacy of pulseless perfusion versus pulsatile perfusion in the recovery of end-organ function has not been fully determined. In this study, the efficacy of pulseless perfusion compared to pulsatile perfusion on the recovery of renal function after a 30 min period of normothermic ischemia was examined. Pigs were randomly assigned to four groups. In all groups, acute renal ischemia was induced by clamping both renal arteries for 30 min. Reperfusion for 120 min was performed using either pulsatile perfusion or pulseless perfusion at 65 +/- 1.6 mm Hg (Groups I [pulsatile] and II [pulseless]) and at 40 +/- 1.1 mm Hg (Groups III [pulsatile] and IV [pulseless]). After reperfusion, renal blood flow, hemodynamic power (pressure * flow: hemodynamic power), oxygen consumption (VO2), tissue ATP, and urine output (UO) in Groups I, II, and III were significantly higher than in Group IV (p < .01 by ANOVA). Histopathologic examinations were not significantly different between groups. Under hypotensive conditions, pulsatile perfusion improves hemodynamic power delivery to the organ c...Continue Reading

Citations

Oct 20, 2005·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Satoshi Saito, Tomohiro Nishinaka
Oct 23, 2004·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Kenneth N LitwakGeorge M Pantalos
Apr 22, 2009·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Andrew H SmithMary B Taylor
Jun 15, 2010·Cardiovascular Engineering·James F AntakiHarvey S Borovetz
Jun 7, 2003·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Kazuyoshi FukunagaYasuhiro Fukui

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