Effect of pulse duration on size and character of the lesion in retinal photocoagulation

Archives of Ophthalmology
Atul JainDaniel Palanker

Abstract

To systematically evaluate the effects of laser beam size, power, and pulse duration of 1 to 100 milliseconds on the characteristics of ophthalmoscopically visible retinal coagulation lesions. A 532-nm Nd:YAG laser was used to irradiate 36 retinas in Dutch Belt rabbits with retinal beam sizes of 66, 132, and 330 mum. Lesions were clinically graded 1 minute after placement, their size measured by digital imaging, and their depth assessed histologically at different time points. Retinal lesion size increased linearly with laser power and logarithmically with pulse duration. The width of the therapeutic window, defined by the ratio of the threshold power for producing a rupture to that of a mild coagulation, decreased with decreasing pulse durations. For 132- and 330-mum retinal beam sizes, the therapeutic window declined from 3.9 to 3.0 and 5.4 to 3.7, respectively, as pulse duration decreased from 100 to 20 ms. At pulse durations of 1 millisecond, the therapeutic window decreased to unity, at which point rupture and a mild lesion were equally likely to occur. At shorter pulse durations, the width and axial extent of the retinal lesions are smaller and less dependent on variations in laser power than at longer durations. The widt...Continue Reading

Citations

Jan 2, 2013·Acta Diabetologica·Francesco BandelloClaudia Del Turco
Mar 3, 2011·Journal of Biomedical Optics·Christopher SramekDaniel Palanker
Jun 28, 2012·Journal of Biomedical Optics·Kerstin SchlottRalf Brinkmann
Jun 28, 2012·Journal of Biomedical Optics·Ralf BrinkmannReginald Birngruber
Jul 1, 2008·The British Journal of Ophthalmology·C SanghviP E Stanga
Aug 29, 2009·Clinical Ophthalmology·Dimple ModiLevent Akduman
Mar 27, 2010·Eye·P E Stanga, M M K Muqit
Jul 30, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Masahiko ShimuraKohji Nishida
Jun 11, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Paulo Eduardo StangaGeorge R Marcellino
Oct 12, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ahmad MirshahiMohamad Mehdi Zaferani
Mar 27, 2012·American Journal of Ophthalmology·Daniel Palanker, Mark S Blumenkranz
Sep 21, 2010·Survey of Ophthalmology·Sobha SivaprasadGiorgio Dorin
Sep 8, 2010·Ophthalmology·Masahiko ShimuraTaijii Sakamoto
Dec 2, 2010·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Ajay BhatnagarSamer Elsherbiny
May 17, 2012·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Christopher K SramekDaniel V Palanker
Oct 26, 2010·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Mauricio TuratiDaniel Palanker
Jul 16, 2011·Lasers in Surgery and Medicine·John P M WoodRobert J Casson
Apr 6, 2013·Acta Ophthalmologica·Daniel LavinskyDaniel Palanker
May 31, 2013·Acta Ophthalmologica·Stefan KoinzerJohann Roider
Sep 23, 2011·American Journal of Ophthalmology·Aimee V ChappelowPeter K Kaiser
Oct 20, 2011·IEEE Transactions on Bio-medical Engineering·Nicholas L OpieDavid B Grayden
Jul 13, 2012·Seminars in Ophthalmology·John D PitcherJean-Pierre Hubschman
Aug 28, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Alexandra E HoehStefan Dithmar
Apr 1, 2011·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Abdelrahman G Salman
Feb 20, 2015·Journal of Ophthalmology·Nawat WatanachaiNimitr Ittipunkul
Jun 21, 2016·Lasers in Surgery and Medicine·Glyn ChidlowJohn P M Wood
Jul 14, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Mark SaegerStefan Koinzer

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