PMID: 9187987Jun 1, 1997Paper

Effect of pump flow rate on cerebral blood flow during hypothermic cardiopulmonary bypass in adults

Journal of Cardiothoracic and Vascular Anesthesia
D J CookW C Oliver

Abstract

The purpose of this study was to examine the effect of cardiopulmonary bypass flow rate on cerebral blood flow and cerebral metabolic rate for oxygen during hypothermic (27 degrees C) cardiopulmonary bypass. The investigation was a prospective, randomized study in a tertiary care hospital setting. The 30 participants were volunteer adult cardiac surgical patients at a single institution. The N2O saturation method of Kety and Schmidt was used to determine global cerebral blood flow and metabolic rate during four periods: prebypass, cardiopulmonary bypass (CPB) (27 degrees C) flow rates of 2.3 and 1.2 L/min/m2, and 30 minutes post-CPB. Anesthesia consisted of fentanyl and midazolam; pH management was alpha-stat, and mean arterial pressure was maintained at 50 to 70 mmHg throughout CPB. In the context of an unchanged mean arterial pressure, the pump flow did not affect cerebral blood flow or metabolic rate during hypothermic CPB. Systemic venous oxygen saturation was also maintained during reduced flow at 27 degrees C. Hemodilution during hypothermic CPB maintained cerebral blood flow at prebypass levels. In the postbypass period, persistent hemodilution resulted in an elevated cerebral blood flow. Brain oxygenation is well mainta...Continue Reading

References

Feb 1, 1989·The Journal of Thoracic and Cardiovascular Surgery·Y SomaT Inoue
Apr 1, 1987·The Annals of Thoracic Surgery·P JohnssonE Ståhl
Sep 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·N A Lassen
Mar 1, 1974·British Journal of Anaesthesia·D C White, M J Halsey
Dec 1, 1995·The Annals of Thoracic Surgery·D J CookR D Bryce

❮ Previous
Next ❯

Citations

Mar 29, 2000·The Annals of Thoracic Surgery·D J CookT A Orszulak
Dec 6, 2001·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·P D Raymond, N A Marsh
Oct 3, 2001·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·K MoriE W Dickson
Apr 18, 2009·Anesthesia and Analgesia·Glenn S MurphyRobert C Groom
Nov 23, 2011·Anesthesia and Analgesia·Brijen JoshiCharles W Hogue
Feb 24, 2006·Journal of Cardiac Surgery·Peter K Smith
Mar 4, 2000·Journal of Cardiothoracic and Vascular Anesthesia·H SungurtekinD J Cook
May 16, 2015·Journal of Cardiothoracic and Vascular Anesthesia·Arthur NeuschwanderRomain Pirracchio
Nov 22, 2014·Medical & Biological Engineering & Computing·Ervin E ŠeverdijaJos G Maessen
Apr 16, 2016·Nephrology·Annette L MazzoneJonathan M Gleadle
Jun 1, 2001·The Journal of Thoracic and Cardiovascular Surgery·K HashimotoS Takeuchi
Nov 24, 2016·International Journal of Molecular Sciences·Aida SalamehNorbert Klein
Apr 1, 2014·Seminars in Cardiothoracic and Vascular Anesthesia·Jayanta MukherjiSteven B Edelstein
Apr 15, 2014·Seminars in Cardiothoracic and Vascular Anesthesia·Allison Bechtel, Julie Huffmyer
Nov 1, 2017·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Chi Bum AhnKuk Hui Son

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Polyendocrinopathies

Autoimmune polyendocrinopathies, also called polyglandular autoimmune syndromes (PGASs), or polyendocrine autoimmune syndromes(PASs), are a heterogeneous group of rare diseases characterized by autoimmune activity against more than one endocrine organ, although non-endocrine organs can be affected. Discover the latest research on autoimmune polyendocrinopathies here.

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.