Effect of punch tip geometry and embossment on the punch tip adherence of a model ibuprofen formulation

The Journal of Pharmacy and Pharmacology
Matthew RobertsA Mark Dyas

Abstract

The sticking of a model ibuprofen-lactose formulation with respect to compaction force, punch tip geometry and punch tip embossment was assessed. Compaction was performed at 10, 25 or 40 kN using an instrumented single-punch tablet press. Three sets of 'normal' concave punches were used to evaluate the influence of punch curvature and diameter. The punches were 10, 11 and 12 mm in diameter, respectively. The 10-mm punch was embossed with a letter 'A' logo to assess the influence of an embossment on sticking. Flat-faced punches (12.5 mm) were used for comparison with the concave tooling. Surface profiles (Taylor Hobson Talysurf 120) of the upper punch faces were obtained to evaluate the surface quality of the tooling used. Following compaction, ibuprofen attached to the upper punch face was quantified by spectroscopy. Increasing punch curvature from flat-faced punches to concave decreased sticking. Altering punch diameter of the concave punches had no effect on sticking when expressed as microg mm(-2). The embossed letter 'A' logo increased sticking considerably owing to the probable concentration of shear stresses at the lateral faces of the embossed logo.

References

Dec 1, 1980·The Journal of Pharmacy and Pharmacology·D Sixsmith
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Nov 8, 2003·The Journal of Pharmacy and Pharmacology·Matthew RobertsPhilip H Rowe

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Citations

Aug 15, 2013·Pharmaceutical Research·Vrushali WaknisAjit S Narang
Dec 21, 2011·Drug Development and Industrial Pharmacy·Daryl M Simmons, Daniel S Gierer
Jul 6, 2011·International Journal of Pharmaceutics·Corinna TissenPeter Kleinebudde
Jan 20, 2010·International Journal of Pharmaceutics·Feiyan Jin, Aditya Tatavarti
Feb 19, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Sarsvatkumar PatelArvind Kumar Bansal
May 7, 2016·Chemical & Pharmaceutical Bulletin·Shohei NakamuraHiroshi Yuasa
Sep 22, 2016·Journal of Pharmaceutical Sciences·Shubhajit PaulChangquan Calvin Sun
Mar 4, 2018·Drug Development and Industrial Pharmacy·Claudia Al-KarawiClaudia S Leopold
Feb 15, 2020·Molecular Pharmaceutics·Shubhajit PaulChangquan Calvin Sun

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