Effect of purpose in life on the relation between Alzheimer disease pathologic changes on cognitive function in advanced age.

Archives of General Psychiatry
Patricia A BoyleDavid A Bennett

Abstract

Purpose in life is associated with a substantially reduced risk of Alzheimer disease (AD), but the neurobiologic basis of this protective effect remains unknown. To test the hypothesis that purpose in life reduces the deleterious effects of AD pathologic changes on cognition in advanced age. A longitudinal, epidemiologic, clinicopathologic study of aging was conducted that included detailed annual clinical evaluations and brain autopsy. Two hundred forty-six community-based older persons from the Rush Memory and Aging Project participated. Purpose in life was assessed via structured interview, and cognitive function was evaluated annually and proximate to death. On postmortem examination, 3 indexes of AD pathologic features were quantified: global AD pathologic changes, amyloid, and tangles. The associations of disease pathologic changes and purpose in life with cognition were examined using linear regression and mixed models. Purpose in life modified the association between the global measure of AD pathologic changes and cognition (mean [SE] parameter estimate, 0.532 [0.211]; P = .01), such that participants who reported higher levels of purpose in life exhibited better cognitive function despite the burden of the disease. Pur...Continue Reading

References

Oct 1, 1995·Journal of Personality and Social Psychology·C D Ryff, C L Keyes
Jan 1, 1996·Psychotherapy and Psychosomatics·C D Ryff, B Singer
Sep 19, 1997·Journal of Personality and Social Psychology·P S Schmutte, C D Ryff
Apr 13, 2001·Current Opinion in Neurobiology·R Adolphs
Jul 12, 2002·Annals of Neurology·Kathryn P RileyWilliam R Markesbery
Jun 20, 2003·Journal of Clinical and Experimental Neuropsychology·Nikolaos Scarmeas, Yaakov Stern
Sep 7, 2004·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Carol D RyffGayle Dienberg Love
Oct 8, 2005·Journal of the International Neuropsychological Society : JINS·Barbara A Wilson
Nov 25, 2005·Journal of Geriatric Psychiatry and Neurology·James A MortimerDavid A Snowdon
Dec 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·Elliot M FriedmanCarol D Ryff
Mar 2, 2006·Psychotherapy and Psychosomatics·Carol D RyffBurton Singer
Nov 30, 2006·Experimental Aging Research·Lisa L BarnesDavid A Bennett
Jan 25, 2007·Psychosomatic Medicine·Robert S WilsonDavid A Bennett
Jun 15, 2007·Neurology·R S WilsonD A Bennett
Sep 6, 2008·Annual Review of Psychology·Ralph Adolphs
May 6, 2009·Psychosomatic Medicine·Patricia A BoyleDavid A Bennett
May 27, 2009·Neuropsychologia·Yaakov Stern
Sep 15, 2009·Journal of Alzheimer's Disease : JAD·Julie A SchneiderDavid A Bennett
Nov 13, 2009·Neuropsychology Review·Karen M RodrigueDenise C Park
Apr 8, 2010·Annals of Neurology·Dorene M RentzKeith A Johnson
May 28, 2010·International Journal of Aging & Human Development·Pia HedbergChristine Brulin
Aug 25, 2010·Psychology and Aging·Cynthia H PhelanSusan M Heidrich
Dec 7, 2010·Journal of Substance Abuse Treatment·Rosemarie A MartinDamaris J Rohsenow
Apr 22, 2011·Neurobiology of Aging·Gregory A JichaPeter T Nelson

❮ Previous
Next ❯

Citations

Nov 16, 2013·PloS One·Stacey M SchaeferRichard J Davidson
Dec 21, 2013·Acta Neuropathologica·David A BennettJulie A Schneider
May 6, 2014·European Journal of Epidemiology·Carole DufouilFrançoise Forette
Feb 20, 2014·Progress in Neurobiology·Anders M FjellUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Feb 21, 2013·Psychology and Aging·Robert S WilsonDavid A Bennett
Mar 6, 2016·Journal of the Neurological Sciences·Kristen R HollingerAdam I Kaplin
Oct 31, 2015·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration
Apr 10, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Stephen T ChenDavid A Merrill
Oct 28, 2015·Journal of Gerontological Nursing·Karen Love, Elia Femia
Jun 27, 2013·Annals of Neurology·Patricia A BoyleDavid A Bennett
Mar 13, 2014·Journal of Internal Medicine·A SolomonM Kivipelto
Jan 15, 2014·Biochemical Pharmacology·Bushra ImtiazHilkka Soininen
Jul 9, 2016·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Mark E Kunik
Apr 11, 2017·International Journal of Aging & Human Development·Justine IrvingAileen Collier
Feb 18, 2017·Journal of Alzheimer's Disease : JAD·Morgan RobinsonFrancis T Hane
Aug 16, 2015·Journal of Geriatric Psychiatry and Neurology·Surbhi C TrivediCharles Pinto
May 22, 2018·Applied Neuropsychology. Adult·John J Randolph
Jun 6, 2018·Journal of Alzheimer's Disease : JAD·David A BennettJulie A Schneider
Feb 21, 2018·American Journal of Men's Health·Stephen NevilleFiona Alpass
Mar 21, 2015·Stroke; a Journal of Cerebral Circulation·Lei YuDavid A Bennett
Nov 14, 2018·Annals of Neurology·Patricia A BoyleDavid A Bennett
Mar 15, 2018·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Courtney A PolenickKira S Birditt
Sep 12, 2017·Journal of the American Geriatrics Society·Jane A EmersonCynthia L Leibson
Jan 16, 2019·Annual Review of Public Health·Bryan D James, David A Bennett
Mar 30, 2019·Social Cognitive and Affective Neuroscience·Laetitia Mwilambwe-TshiloboR Nathan Spreng
Apr 16, 2019·Annals of Internal Medicine·Patricia A BoyleDavid A Bennett
Feb 8, 2018·Journal of Telemedicine and Telecare·Giuseppa MarescaUNKNOWN Sicilian Teleneurology Group
Feb 1, 2018·The Gerontologist·Wingyun Mak, Silvia Sörensen
Feb 12, 2020·PloS One·Gabriele CattaneoAlvaro Pascual-Leone
Feb 8, 2019·Neurology·Robert S WilsonDavid A Bennett
Jul 10, 2019·Clinical Gerontologist·Katherine G DennySarah Tomaszewski Farias
Apr 30, 2020·PloS One·Shahram OveisgharanAron S Buchman
Mar 17, 2020·Journal of Alzheimer's Disease : JAD·Lei YuPatricia A Boyle
Dec 2, 2014·Journal of Psychology in Africa (south of the Sahara, the Caribbean, and Afro-Latin America)·Carol D Ryff
Aug 26, 2020·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Tim D WindsorMary A Luszcz
Oct 1, 2020·Journal of the American Geriatrics Society·Angelina R SutinAntonio Terracciano
May 24, 2017·Current Behavioral Neuroscience Reports·Carol D RyffRichard J Davidson
May 27, 2017·Brain Sciences·Robert S Wilson, David A Bennett
Oct 24, 2017·International Review of Economics·Carol D Ryff
May 29, 2018·American Journal of Health Promotion : AJHP·Sai Krupa DasSusan B Roberts

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

Epidemiology of Aging

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.