Effect of pyridoxine and magnesium on stress-induced gastric ulcers in mice selected for low or high blood magnesium levels

Annals of Nutrition & Metabolism
J G HenrotteR G Boulu

Abstract

Gastric ulcers were induced by immobilization in adult female mice with genetically low (MGL) or high (MGH) blood magnesium levels, obtained by selective breeding at the CSAL-CNRS (Orléans, France). All animals, fed with the same standard diet rich in magnesium, were divided into four groups of 20 animals and injected subcutaneously every 2 days for 10 days with isotonic saline (group 1), pyridoxine chlorhydrate 1.11 mg/kg in saline (group 2), magnesium lactate 149 mg/kg in saline (group 3) or both pyridoxine and magnesium (group 4). Subsequently, animals were submitted to a complete fast and an immobilization stress for 17 h. Then, they were sacrificed and the gastric mucosa was dissected for ulcer count. Among the controls (group 1), the mean number of gastric ulcers per mouse was significantly larger in the MGL than in the MGH line (p = 0.0003). In the MGH line, no significant differences were observed between control and treated groups. In the MGL line, pyridoxine associated or not with magnesium (groups 2 and 4) significantly reduced the mean number of ulcers. Magnesium treatment alone (group 3) had little effect. These results can be compared with the greater vulnerability to stress previously observed in Swiss mice fed w...Continue Reading

Citations

May 8, 2004·Metabolism: Clinical and Experimental·C Feillet-CoudrayA Mazur
Apr 10, 2002·Critical Care Nursing Clinics of North America·Jeanne Flannery, Denise A Tucker
May 20, 1998·Scandinavian Journal of Clinical and Laboratory Investigation·D L Heath, R Vink
Jan 12, 2001·Physiological Reviews·L J DaiG A Quamme
Dec 3, 2020·Nutrients·Gisèle PickeringEtienne Pouteau

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