Effect of qi-tonifying and stasis-eliminating therapy on expression of vascular endothelial growth factor and its receptors Flt-1, Flk-1 in the brain of intracerebral hemorrhagic rats

Chinese Journal of Integrative Medicine
Zong-qi ZhangDing-zhu Shen

Abstract

To investigate the effects and mechanism of qi-tonifying and stasis-eliminating (QTSE) therapy on the expression of vascular endothelial growth factor (VEGF) and its receptors Flt-1 and Flk-1 in the brains of intracerebral hemorrhagic (model) rats. One hundred and eighty Sprague-Dawley rats were randomly divided into six groups: the normal group (n=5), the sham-operative (SO) group (n=35), the model group (n=35), the QTSE group (n=35), the QT group (n=35) and the SE group (n=35). All the rats except those in the normal group and SO group were established into an intracerebral hemorrhage(ICH) model by intracerebral injection of collagenase type VII and the latter three were orally administered with Buyang Huanwu Decoction (a classical recipe for QTSE) or with some of its components for qi-tonification and for stasis-elimination, respectively. To the other three groups, normal saline solutions were given instead. Behavioral tests were carried out in the animals randomly chosen from each group on days 1, 2, 4, 7, 14, 21 and 28 after modeling. The expressions of VEGF, Flk-1 and Flt-1 were determined by immunohistochemistry and the number of vascular segments with positive expression in the injured brain area of the rats was calcula...Continue Reading

References

Oct 5, 2002·Stroke; a Journal of Cerebral Circulation·Ya HuaGuohua Xi
Nov 2, 2002·Stroke; a Journal of Cerebral Circulation·James M GebelJoseph P Broderick
Jun 11, 2005·Stroke; a Journal of Cerebral Circulation·Yiqian ZhuGuo-Yuan Yang
Jul 26, 2005·Stroke; a Journal of Cerebral Circulation·Yun SunJohn H Zhang

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Citations

Oct 31, 2013·Chinese Journal of Integrative Medicine·A-li YangTao Tang
Nov 5, 2014·Neural Regeneration Research·Qingchun MuHaiyan Huang
Sep 3, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Huihua ChenRong Lu

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