Abstract
QSOX1 (quiescin-sulfhydryl oxidase 1) is involved in various processes, including apoptosis and the development of breast diseases. Here, we investigated the effect of QSOX1 on the meat quality of Simmental cattle by analyzing the correlation between QSOX1 single nucleotide polymorphisms (SNPs), I2 204 C>T and I2 378 C>T, and certain meat quality traits. The effects of QSOX1 on triglyceride synthesis and cell apoptosis were further validated by gene silencing or overexpression in bovine fetal fibroblasts and mammary epithelial cells. The results showed that I2 204 C>T and I2 378 C>T had significant correlations with loin thickness, hind hoof weight, fat coverage, liver weight, heart weight, marbling and back fat thickness (P<0.05). QSOX1 overexpression also increased triglyceride production and suppressed apoptosis. In summary, QSOX1 is an important factor for meat quality, lipid metabolism, and cell apoptosis, indicating that QSOX1 could be used as a biomarker to assist in breeding cattle with superior meat.
References
Jan 8, 1999·Genomics·D L CoppockS Gilleran
Aug 9, 2001·EMBO Reports·H LangeR Lill
Mar 3, 2007·The Biochemical Journal·Seema ChakravarthiNeil J Bulleid
Dec 15, 2010·Journal of Biochemistry·Wenyun ZhengYi Yang
Jan 12, 2012·Microbial Cell Factories·Romany N N AbskharonAlexandre Wohlkonig
Jul 7, 2012·European Heart Journal·Wolfram Doehner
Jan 8, 2013·Gene·Jing TianRunjun Yang
May 18, 2013·Breast Cancer Research : BCR·Padmalaya DasLynne-Marie Postovit
Sep 7, 2013·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Chen-Ye ShiWen-Hui Lou
Nov 12, 2013·Molecular Biology Reports·X B FangR J Yang
Dec 18, 2013·Placenta·J SabenK Shankar
Jan 29, 2014·Free Radical Biology & Medicine·Benjamin A IsraelColin Thorpe
Apr 8, 2014·European Journal of Histochemistry : EJH·D G B AraújoL de Noronha
May 16, 2014·Journal of Cellular and Molecular Medicine·Xiaoru SunXiangdong Wang
Mar 15, 2015·Biochimica Et Biophysica Acta·Beatriz E BorgesLia S Nakao
Mar 19, 2015·DNA and Cell Biology·Xiaojun ZhangBoxing Sun
Apr 25, 2015·Diagnostic Pathology·Ana Cristina Lira SobralLucia de Noronha
Jul 15, 2015·Oncotarget·Paul D HanavanDouglas F Lake
Jun 7, 2016·Scandinavian Journal of Medicine & Science in Sports·J J BassP J Atherton
Jun 15, 2016·BMC Genomics·Joaquim Manoel da SilvaAlexandre Rodrigues Caetano
Citations
Jan 7, 2021·Animal Biotechnology·Yanghai ZhangChuanying Pan
Nov 10, 2020·Journal of Dairy Science·Ming-Qi WangBao Yuan
Dec 24, 2021·PloS One·Asep GunawanMuhammad Jasim Uddin