Effect of Quercetin on Haematobiochemical and Histological Changes in the Liver of Polychlorined Biphenyls-Induced Adult Male Wistar Rats

Journal of Biomarkers
Kandaswamy SelvakumarJagadeesan Arunakaran

Abstract

Polychlorinated biphenyls exposure damages the rat liver cells. Hematological parameters such as hemoglobin, packed cell volume, red-blood cells, white-blood cells, neutrophils, platelet counts, and RBC indices were significantly decreased. Polymorphs, eosinophil counts, and erythrocyte sedimentation rate were significantly increased. Serum liver enzymes such as aspartate transaminase, alanine transaminase, alkaline phosphatase, and gamma-glutamyl transferase were increased by PCBs treatment. Serum lipid profiles such as cholesterol, triglycerides, low-density lipoproteins and very-low-density lipoproteins were increased in PCBs-treated rats. High-density lipoprotein, total protein, albumin, globulin levels, and albumin/globulin ratio were also decreased after PCB exposure. Then levels of sodium, potassium, chloride, and bicarbonate were also altered. Serum glucose levels were increased along with total bilirubin after PCBs exposure. Simultaneous quercetin supplementation significantly protected the PCBs-induced changes of hematobiochemical parameters. Thus, quercetin shows a protective role against PCBs-induced alterations in the hematological and biochemical parameters.

References

Mar 1, 1975·The Journal of Pediatrics·J KapitulnikA Russell
Jul 1, 1991·British Journal of Anaesthesia·D C Ray, G B Drummond
Oct 1, 1985·The Journal of Clinical Investigation·Y ShenkerR J Grekin
Sep 1, 1996·The Journal of International Medical Research·K DurakK Turan
Apr 1, 1997·Toxicology and Applied Pharmacology·S P NetkeA Niedzwiecki
Mar 4, 2000·Free Radical Biology & Medicine·R G Allen, M Tresini
Mar 14, 2002·Toxicologic Pathology·Gary M Williams, Michael J Iatropoulos
Jul 29, 2003·Biochemistry. Biokhimii︠a︡·A I Potapovich, V A Kostyuk
Oct 31, 2003·Journal of Cellular Biochemistry·Anthony PilorgetRichard Béliveau
Dec 9, 2003·European Journal of Pharmacology·Eun Jeong ChoiByung Ho Lee
Nov 13, 2004·Journal of Pharmacological Sciences·Hyun Pyo KimSam Sik Kang
Dec 5, 2006·Neurotoxicology·Prabhu VenkataramanJagadeesan Arunakaran
Apr 14, 2007·Digestive Diseases and Sciences·Pavanato Maria AmáliaLlesuy Susana Francisca
Apr 28, 2009·Environment International·Karin NorströmKeri C Hornbuckle
Nov 26, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·K SelvakumarJ Arunakaran
Apr 14, 2010·Environmental Science & Technology·Lisa A RodenburgGregory J Cavallo
Nov 26, 2010·World Journal of Gastroenterology : WJG·Marcelo-G BinkerLaura-I Cosen-Binker
Mar 25, 2011·Toxicology International·Tarun BalaniA M Thaker
Dec 1, 2011·Neurochemical Research·Kandaswamy SelvakumarJagadeesan Arunakaran

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Citations

Feb 13, 2019·Drug and Chemical Toxicology·Simranjeet KaurD K Dhawan
May 27, 2014·Natural Products and Bioprospecting·Rasiah Pratheepa Kumari, Kumarasamy Anbarasu
Nov 28, 2016·Environmental Science and Pollution Research International·Rasha T AlamTamer S Imam
Dec 8, 2020·BioMed Research International·Pedro A Machado-JuniorSílvia D Cangussú

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