Abstract
Polychlorinated biphenyls exposure damages the rat liver cells. Hematological parameters such as hemoglobin, packed cell volume, red-blood cells, white-blood cells, neutrophils, platelet counts, and RBC indices were significantly decreased. Polymorphs, eosinophil counts, and erythrocyte sedimentation rate were significantly increased. Serum liver enzymes such as aspartate transaminase, alanine transaminase, alkaline phosphatase, and gamma-glutamyl transferase were increased by PCBs treatment. Serum lipid profiles such as cholesterol, triglycerides, low-density lipoproteins and very-low-density lipoproteins were increased in PCBs-treated rats. High-density lipoprotein, total protein, albumin, globulin levels, and albumin/globulin ratio were also decreased after PCB exposure. Then levels of sodium, potassium, chloride, and bicarbonate were also altered. Serum glucose levels were increased along with total bilirubin after PCBs exposure. Simultaneous quercetin supplementation significantly protected the PCBs-induced changes of hematobiochemical parameters. Thus, quercetin shows a protective role against PCBs-induced alterations in the hematological and biochemical parameters.
References
Dec 1, 1979·British Journal of Anaesthesia·J P FeeS A McMillan
Mar 1, 1975·The Journal of Pediatrics·J KapitulnikA Russell
Jul 1, 1991·British Journal of Anaesthesia·D C Ray, G B Drummond
Dec 1, 1989·Anesthesiology·R C LindP D Hall
Oct 1, 1985·The Journal of Clinical Investigation·Y ShenkerR J Grekin
Sep 1, 1996·The Journal of International Medical Research·K DurakK Turan
Apr 1, 1997·Toxicology and Applied Pharmacology·S P NetkeA Niedzwiecki
Aug 7, 1999·The New England Journal of Medicine·H B RubinsJ Wittes
Sep 1, 1999·Biological Trace Element Research·M Naziroğlu
Mar 4, 2000·Free Radical Biology & Medicine·R G Allen, M Tresini
Jun 23, 2000·Neuroscience Letters·S LeeS Kim
Oct 30, 2001·Il Farmaco·T GuardiaL E Pelzer
Mar 14, 2002·Toxicologic Pathology·Gary M Williams, Michael J Iatropoulos
Nov 2, 2002·The Journal of Physiology·Luc J TeppemaAlbert Dahan
Jul 29, 2003·Biochemistry. Biokhimii︠a︡·A I Potapovich, V A Kostyuk
Aug 2, 2003·Journal of Pharmacological Sciences·Yukiko MorimotoYoshihiro Nakata
Oct 31, 2003·Journal of Cellular Biochemistry·Anthony PilorgetRichard Béliveau
Dec 9, 2003·European Journal of Pharmacology·Eun Jeong ChoiByung Ho Lee
Mar 10, 2004·The Journal of Pharmacy and Pharmacology·Takako YokozawaEun Ju Cho
Nov 13, 2004·Journal of Pharmacological Sciences·Hyun Pyo KimSam Sik Kang
Dec 14, 2004·Toxicology·M G ShalanA El-Refaie
Apr 12, 2005·Journal of Chemical Neuroanatomy·Ahmet GurelOguz Aslan Ozen
Jun 16, 2005·Toxicology·G KrishnamoorthyJ Arunakaran
May 10, 2006·Journal of Pharmacological Sciences·Aleksandra NovakovicHelmut Heinle
Dec 5, 2006·Neurotoxicology·Prabhu VenkataramanJagadeesan Arunakaran
Apr 14, 2007·Digestive Diseases and Sciences·Pavanato Maria AmáliaLlesuy Susana Francisca
Aug 2, 2007·Journal of Pharmacological Sciences·Fengling PuMichihiro Fujiwara
May 27, 2008·Reproductive Toxicology·Palaniappan MurugesanJagadeesan Arunakaran
Apr 25, 2009·Basic & Clinical Pharmacology & Toxicology·Prabhu VenkataramanJagadeesan Arunakaran
Apr 28, 2009·Environment International·Karin NorströmKeri C Hornbuckle
Nov 17, 2009·Neuroscience Research·Prabhu VenkataramanJagadeesan Arunakaran
Nov 26, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·K SelvakumarJ Arunakaran
Apr 14, 2010·Environmental Science & Technology·Lisa A RodenburgGregory J Cavallo
Jul 27, 2010·Molecular and Cellular Biochemistry·Kalimuthu SenthilkumarJagadeesan Arunakaran
Nov 26, 2010·World Journal of Gastroenterology : WJG·Marcelo-G BinkerLaura-I Cosen-Binker
Feb 11, 2011·Cell Biochemistry and Function·Kalimuthu SenthilkumarJagadeesan Arunakaran
Mar 25, 2011·Toxicology International·Tarun BalaniA M Thaker
Apr 8, 2011·Neurochemical Research·Rasiah Pratheepa KumariJagadeesan Arunakaran
Jul 13, 2011·Neurotoxicity Research·Senthamilselvan BavithraJagadeesan Arunakaran
Dec 1, 2011·Neurochemical Research·Kandaswamy SelvakumarJagadeesan Arunakaran
Citations
Feb 13, 2019·Drug and Chemical Toxicology·Simranjeet KaurD K Dhawan
Dec 27, 2019·Journal of Food Biochemistry·Sunday O OyedemiOlayinka A Aiyegoro
Oct 17, 2019·Phytotherapy Research : PTR·Ravindra Babu PingiliSirisha Koppula
Oct 28, 2016·Andrologia·T Sathish KumarJ Arunakaran
Aug 10, 2017·Environmental Science and Pollution Research International·Nehad M Abd El-MoneamAsmaa Nabil-Adam
May 27, 2014·Natural Products and Bioprospecting·Rasiah Pratheepa Kumari, Kumarasamy Anbarasu
Nov 28, 2016·Environmental Science and Pollution Research International·Rasha T AlamTamer S Imam
Jan 31, 2019·Environmental Science and Pollution Research International·Gehan M BadrAshraf M Abdel-Moneim
Feb 26, 2020·Clinical Nutrition Research·Yahya PasdarMahboobe Hosseinikia
Dec 8, 2020·BioMed Research International·Pedro A Machado-JuniorSílvia D Cangussú