Abstract
The effect of quinapril or metoprolol on heart rate variability (HRV) indexes was studied in patients who had recovered from acute myocardial infarction. Patients with stable coronary artery disease and normal volunteers were used as controls. Sixty patients with uncomplicated myocardial infarction (aged 32 to 74 years [mean 56.7]) were randomized to quinapril (n = 25), metoprolol (n = 25), and placebo (n = 10). HRV was assessed 5 days (baseline) and 35 days after the onset of acute myocardial infarction. After the baseline studies, the post-myocardial infarction patients were treated with metoprolol (50 to 100 mg/day), quinapril (5 to 10 mg/day), or placebo. Twenty patients with stable coronary artery disease and 20 healthy volunteers, age- and sex-matched to myocardial infarction patients, were used as controls. Compared with placebo, quinapril and metoprolol increased HRV indexes significantly 35 days after the onset of myocardial infarction. HRV indexes were not statistically different between the 2 treatment groups. At baseline and after therapy, HRV was similar in patients with anterior or inferior wall myocardial infarction. HRV 35 days after the onset of myocardial infarction was not different from HRV in patients with ...Continue Reading
References
Oct 1, 1977·Annals of Internal Medicine·H BoudoulasG Dalamangas
Jun 15, 1992·The American Journal of Cardiology·J N TownendW A Littler
Jan 1, 1991·British Heart Journal·T R CrippsA J Camm
Sep 1, 1991·Journal of the American College of Cardiology·T G FarrellA J Camm
Aug 15, 1991·The American Journal of Cardiology·O OdemuyiwaJ Camm
Dec 11, 1991·Journal of the American College of Cardiology·J T BiggerW J Schneider
Feb 11, 1991·Journal of the American College of Cardiology·J R CookL M Rolnitzky
Nov 1, 1990·American Heart Journal·K J OsterzielW Kübler
Mar 1, 1989·Circulation·S M HeilbrunnM B Fowler
Feb 1, 1986·The American Journal of Cardiology·H BoudoulasA M Weissler
Dec 1, 1987·The American Journal of Cardiology·F LombardiA Malliani
Feb 1, 1987·The American Journal of Cardiology·R E KleigerA J Moss
Jan 1, 1986·Hypertension·F LombardiA Malliani
Feb 1, 1972·Circulation Research·T G PickeringP Sleight
Jun 9, 1983·Nature·M SchwabD George
Oct 1, 1983·Journal of the American College of Cardiology
Aug 15, 1994·The American Journal of Cardiology·G SandroneF Lombardi
Apr 1, 1994·The American Journal of Cardiology·S VaishnavA D Timmis
May 1, 1994·Journal of the American College of Cardiology·M J NiemeläH V Huikuri
Feb 1, 1993·European Heart Journal·J N TownendM K Davies
Mar 1, 1993·Journal of the American College of Cardiology·P F BinkleyR J Cody
Citations
Mar 14, 2001·European Journal of Heart Failure·G MalfattoM Facchini
Apr 18, 2002·European Journal of Heart Failure·Gabriella MalfattoMario Facchini
Jun 1, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M LickerD R Morel
Jan 12, 1999·Diabetes Research and Clinical Practice·D T KaramitsosA G Kontopoulos
Jul 25, 1997·International Journal of Cardiology·L LurjeA Hjalmarson
Jun 25, 1999·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·S Dincă-PanaitescuR Negoescu
Aug 21, 2002·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·Radu NegoesAlin Achim
May 28, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Yusei AbeMasaru Nasu
Feb 27, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Yusei AbeMasaru Nasu
Sep 19, 2009·Expert Opinion on Drug Metabolism & Toxicology·Arne Georg KiebackThorsten Reffelmann
Sep 4, 2007·Progress in Cardiovascular Diseases·Gaetano Antonio Lanza
Sep 7, 2004·Clinical Cardiology·Ilke SipahiOzen Guven
Jul 1, 2011·Clinical Cardiology·Reginald Liew
Jun 29, 2005·International Journal of Cardiology·Emanuele BertagliaPietro Pascotto
Apr 29, 1998·The American Journal of Cardiology·G MalfattoG Leonetti
Sep 1, 1996·The American Journal of Cardiology·D BonaduceM Petretta
Mar 18, 1999·Journal of the American College of Cardiology·M J DomanskiM A Pfeffer
Jan 11, 2003·The American Journal of Cardiology·Rachel LampertForrester A Lee
Nov 24, 1999·The American Journal of Cardiology·A G KontopoulosH Boudoulas
Oct 1, 2016·Nutrients·Michelle C MannSofia B Ahmed
Aug 5, 2008·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Robert P NolanJohn S Floras
Feb 7, 2017·World Journal of Cardiology·Leonida CompostellaFabio Bellotto
Aug 26, 1998·Circulation·J A TaylorD L Eckberg
Jun 10, 2015·Hypertension·Michelle C MannSofia B Ahmed
May 13, 1999·Anesthesia and Analgesia·C KeylJ Hobbhahn
Aug 24, 2013·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Ercan ErdoganOmer Göktekin