Effect of R factors and other plasmids on ultraviolet susceptibility and host cell reactivation property of Escherichia coli.

Journal of Bacteriology
A G Siccardi

Abstract

Some R factors, like some colicin factors, confer partial protection against the bactericidal effect of ultraviolet (UV) irradiation. Of 31 plasmids (17 R, 3 col, and 11 R-col factors) tested in Escherichia coli K-12, 15 protected, 11 had little or no effect, and 5 caused increased UV susceptibility. The effect of representative plasmids was qualitatively the same in K-12 of wild-type UV sensitivity, lambda-lysogenic or non-lysogenic, and in UV-sensitive mutants of classes uvrA, uvrB, uvrC, and recA (except that a sensitizing factor did not increase the sensitivity of two recA hosts). It is inferred that the UV-protecting effect of some plasmids does not result from their specifying enzymes similar to those deficient in such mutants. UV killing of multiply auxotrophic K-12, of wild-type sensitivity or recA or uvrC, was reduced by deprivation of required amino acids for 2 hr before irradiation, and further reduced if "starvation" was continued for 2 hr after irradiation. The plasmids tested in these conditions produced qualitatively the same effects as in nonstarved cells-except that in K-12 of wild-type UV sensitivity the effect of protecting plasmids was reversed (i.e. they caused decreased survival) when the cells were starve...Continue Reading

References

Jun 1, 1966·Journal of Molecular Biology·R RowndA Nakamura
Jan 1, 1967·Annual Review of Microbiology·M Nomura
Jan 1, 1968·Annual Review of Biochemistry·P Howard-Flanders
Oct 20, 1966·Biochemical and Biophysical Research Communications·T TakanoT Fukasawa
Sep 1, 1967·Journal of Bacteriology·D R Helinski, H R Herschman
Oct 1, 1954·Journal of General Microbiology·R C CLOWES, D ROWLEY

❮ Previous
Next ❯

Citations

Jan 1, 1980·Molecular & General Genetics : MGG·L S Chernin, M I Ovadis
Jan 1, 1981·Molecular & General Genetics : MGG·K McCann, C H Clarke
Dec 30, 1977·Molecular & General Genetics : MGG·Y S KondratievA G Skavronskaya
Jan 2, 1979·Molecular & General Genetics : MGG·K E Mortelmans, B A Stocker
Jan 1, 1984·Molecular & General Genetics : MGG·S B DowdenP Strike
Oct 23, 2016·Journal of Bacteriology·Anthonige Vidya PereraJustin Courcelle
Jan 1, 1975·Journal of Bacteriology·N S Willetts
Dec 1, 1975·Bacteriological Reviews·K G Hardy
Jul 1, 1981·Plasmid·L S Chernin, V S Mikoyan
May 19, 1972·Science·J E Davies, R Rownd

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.