Effect of rabbit anti-human thymocyte globulin on lymphocyte subpopulations and functions following allotransplantation in the rhesus monkey

Transplantation
J M ThomasF Thomas

Abstract

The survival time of skin allografts from RhLA-nonidentical, unrelated donors was increased from a mean of 7.69 days in controls (n = 20) to a mean of 32.53 days in rhesus monkeys (n = 21) receiving a total dose of 250 mg of rabbit anti-human thymocyte globulin (RATG) per kg. Immunological monitoring studies were performed on the peripheral blood of mononuclear cells in control and treated monkeys. After administration of RATG, the percentage of E rosette-forming cells (E-RFC) was greater than 90% depressed, and the percentage of EAC rosette-forming cells was increased 5-fold in the circulation. Significant numbers of RATG-coated cells were detected only during the first week after RATG treatment. The percentage of E-RFC recovered to pretreatment levels within 3 to 4 weeks after RATG treatment, although the absolute E-RFC count remained depressed for 2 to 3 months. In addition, the in vitro proliferative responsiveness to polyclonal mitogens and to allogeneic lymphocytes remained greater than 80% depressed for 2 to 3 months after RATG treatment. The incidence of post-transplant-specific antidonor lymphocyte-mediated cytotoxicity (LMC) was similar in controls (85%) and RATG-treated monkeys (81%), and the appearance of LMC was co...Continue Reading

Citations

Feb 1, 1997·Transplantation Proceedings·X LiuU T Hopt
Jun 1, 1982·Cellular Immunology·P B CampbellT A Tolson
Mar 1, 1980·Clinical Immunology and Immunopathology·J R SchmidtkeJ S Najarian
May 12, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·G WieczorekV Nickeleit

Related Concepts

Metazoa
Anthropoidea
Antibody-Dependent Cellular Cytotoxicity
Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine)
Cell Division Phases
Graft Rejection
Graft Survival
Immunosuppressive Agents
Macaca mulatta
Chinchilla Rabbits

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