Effect of racemic mixture and the (S+)-isomer of ketamine on temporal and spatial summation of pain

British Journal of Anaesthesia
L Arendt-NielsenA M Zbinden

Abstract

We have compared the analgesic efficacy of the racemic mixture and the stereoisomer (S+) of the NMDA antagonist ketamine. In a double-blind, three-way crossover, placebo-controlled study, we assessed the following: pain evoked by small/large area pressure stimuli, pain detection threshold and pain ratings to small/large area of heat stimuli, pain detection threshold and pain rating to heat stimuli of brief/long duration, summation pain threshold and pain ratings to repeated heat/electrical stimuli, side effects and reaction time. Plasma concentrations of 350 ng ml-1 for ketamine (racemic) and 180 ng ml-1 for ketamine (S+) were tried. We found that ketamine (racemic) prolonged the reaction time more than ketamine (S+). Both drugs affected pain caused by repeated stimuli or stimuli of long duration equally or more than a single stimulus of short duration. They also affected pain evoked from large areas equally or more than pain evoked from small areas. The (S+)-isomer was approximately twice as potent as the racemic mixture of ketamine in inhibiting central summation.

Citations

Jan 31, 2012·European Journal of Clinical Pharmacology·Marko A PeltoniemiKlaus T Olkkola
Jul 16, 2002·Pharmacology, Biochemistry, and Behavior·Marian E FundytusAndy Dray
Jul 23, 2002·Neuroscience Letters·Andrew C N ChenLars Arendt-Nielsen
Feb 25, 2000·Journal of Pain and Symptom Management·C N Sang
Dec 25, 2004·Anesthesiology·Sabine Himmelseher, Marcel E Durieux
Sep 1, 2005·Anesthesiology·Yung-Wei HsuChien-Chuan Chen
Jan 11, 2002·The Clinical Journal of Pain·M CuratoloB P Radanov
Sep 24, 2011·Regional Anesthesia and Pain Medicine·Lars Arendt-NielsenAsbjørn M Drewes
Jan 6, 2010·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Y J Zhu, T J Lu
Feb 25, 2003·Anesthesia and Analgesia·Martin LuginbühlMichele Curatolo
Apr 24, 2004·Anesthesia and Analgesia·Helena ArgiriadouEberhard Kochs
Nov 20, 2008·Drugs·Cesare GregorettiFabio Azzeri
Aug 10, 2013·The Journal of the Acoustical Society of America·Abbi M McClinticPierre D Mourad
Nov 4, 2010·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Susan CollinsRoberto S G M Perez
Sep 11, 2009·British Journal of Clinical Pharmacology·Camilla StaahlAsbjørn Mohr Drewes
Aug 22, 2009·British Journal of Clinical Pharmacology·Camilla StaahlAsbjørn Mohr Drewes
Nov 13, 2008·Journal of Veterinary Pharmacology and Therapeutics·A SchmitzM Mevissen
May 10, 2008·Veterinary Anaesthesia and Analgesia·Christoph PeterbauerClaudia Spadavecchia
Jun 4, 2011·Fundamental & Clinical Pharmacology·Marko A PeltoniemiKlaus T Olkkola
Jun 9, 2012·Basic & Clinical Pharmacology & Toxicology·Marko A PeltoniemiKlaus T Olkkola
Nov 10, 2009·European Journal of Pain : EJP·Nora M HagelbergKlaus T Olkkola
Nov 3, 2009·European Journal of Pain : EJP·Maren I BlonkFrank J P M Huygen
Jul 26, 2014·Acta Anaesthesiologica Scandinavica·E D McNicolS Haroutounian
Dec 20, 2008·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Liliana SollazziValter Perilli
Mar 31, 2016·Clinical Pharmacokinetics·Marko A PeltoniemiTeijo I Saari
Aug 24, 2005·Annales Françaises D'anesthèsie Et De Rèanimation·P RichebéG Simonnet
Mar 21, 2003·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Lars Arendt-Nielsen, Hiroyuki Sumikura

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

British Journal of Anaesthesia
Steen Petersen-FelixA M Zbinden
Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
Asako Furuhashi-YonahaShuji Dohi
British Journal of Anaesthesia
Michele CuratoloA M Zbinden
© 2021 Meta ULC. All rights reserved