Effect of radiation dose reduction and iterative reconstruction on computer-aided detection of pulmonary nodules: Intra-individual comparison

European Journal of Radiology
Annemarie M den HarderRicardo P J Budde

Abstract

To evaluate the effect of radiation dose reduction and iterative reconstruction (IR) on the performance of computer-aided detection (CAD) for pulmonary nodules. In this prospective study twenty-five patients were included who were scanned for pulmonary nodule follow-up. Image acquisition was performed at routine dose and three reduced dose levels in a single session by decreasing mAs-values with 45%, 60% and 75%. Tube voltage was fixed at 120 kVp for patients ≥ 80 kg and 100 kVp for patients < 80 kg. Data were reconstructed with filtered back projection (FBP), iDose(4) (levels 1,4,6) and IMR (levels 1-3). All noncalcified solid pulmonary nodules ≥ 4 mm identified by two radiologists in consensus served as the reference standard. Subsequently, nodule volume was measured with CAD software and compared to the reference consensus. The numbers of true-positives, false-positives and missed pulmonary nodules were evaluated as well as the sensitivity. Median effective radiation dose was 2.2 mSv at routine dose and 1.2, 0.9 and 0.6 mSv at respectively 45%, 60% and 75% reduced dose. A total of 28 pulmonary nodules were included. With FBP at routine dose, 89% (25/28) of the nodules were correctly identified by CAD. This was similar at red...Continue Reading

References

Apr 25, 2006·AJR. American Journal of Roentgenology·Ren YuanPeter L Cooperberg
Mar 1, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Giulia VeronesiLorenzo Spaggiari
Mar 18, 2008·Computers in Biology and Medicine·A ReticoA Preite Martinez
Apr 4, 2008·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Ji Young LeeKyung Soo Lee
Jul 31, 2008·Journal of Computer Assisted Tomography·Jin Mo GooKyongtae T Bae
Feb 7, 2009·Radiologic Clinics of North America·Cynthia H McColloughJodie Christner
Jun 19, 2009·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·P A HeinV C Romano
Jul 24, 2014·European Radiology·Matthew S BrownDenise R Aberle
Feb 7, 2015·Journal of Thoracic Imaging·Geoffrey D Rubin
Feb 26, 2015·AJR. American Journal of Roentgenology·Annemarie M den HarderPim A de Jong
May 2, 2015·The European Respiratory Journal·Hans-Ulrich KauczorUNKNOWN European Respiratory Society (ERS)

❮ Previous
Next ❯

Citations

Nov 28, 2017·The British Journal of Radiology·Mario SilvaNicola Sverzellati
Sep 17, 2020·Journal of Computer Assisted Tomography·Kristin JensenAnne Catrine Martinsen
Nov 8, 2018·European Radiology Experimental·Annemarie M den HarderPim A de Jong

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.