PMID: 3744940Jul 1, 1986Paper

Effect of radiation-induced reduction of nitroimidazoles on biologically active DNA

International Journal of Radiation Oncology, Biology, Physics
M V LafleurH Loman

Abstract

Radiation-chemical reductions have been carried out with several nitroimidazoles. Reduction of these drugs in the presence of single-stranded phi chi 174 DNA causes extensive lethal damage. However, relatively stable (end) products, do not contribute to the damage, although glyoxal is potentially toxic. This demonstrates that a short-lived intermediate in the reduction process is responsible. Further, the quantity of damage in the DNA depends on both dose (reduction)-rate and also the nature of the drug.

References

Aug 1, 1974·The British Journal of Radiology·J C AsquithJ A McFadzean
May 1, 1983·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·F J NabbenH Loman
Mar 1, 1982·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·M V Lafleur, H Loman
Aug 1, 1984·International Journal of Radiation Oncology, Biology, Physics·R J KnoxR C Knight
Aug 1, 1984·International Journal of Radiation Oncology, Biology, Physics·A M Rauth
Aug 1, 1984·International Journal of Radiation Oncology, Biology, Physics·J A Raleigh, S F Liu
Jan 15, 1984·Biochemical Pharmacology·R A McClellandR Battistella

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Citations

Jun 5, 2002·Toxicology Letters·Gisell Rodriguez FerreiroMarta Ana Carballo
Oct 19, 2004·Clinical Microbiology Reviews·Sarah L CudmoreGary E Garber
Feb 18, 2016·Organic & Biomolecular Chemistry·Xiao-Bo DingDaniel P Furkert
Jun 12, 2002·Journal of Radiation Research·Mikinori KuwabaraMichihiko Tsujitani

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