PMID: 1901513May 1, 1991Paper

Effect of radiation on the expression of carcinoembryonic antigen of human gastric adenocarcinoma cells

Cancer
M HareyamaK Morita

Abstract

The changes of antigenic expression of cultured human gastric adenocarcinoma MKN45 cells caused by irradiation were investigated to elucidate the immune responses to localized irradiation. The expression of carcinoembryonic antigen (CEA) showed remarkable increases in the culture supernatant and on the surface of the membrane of irradiated cells. The expression of major histocompatibility complex Class I antigen on the membrane also was enhanced by irradiation. In addition, the irradiated cell groups, when analyzed using a CEA-specific probe, showed remarkable increases in the CEA mRNA. These enhancements increased in the 10-Gy and 15-Gy irradiated populations compared with the 5-Gy irradiated population. These results suggest that the enhancement of expression of CEA by radiation takes place at the CEA gene expression (mRNA) level but not at the protein level.

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Citations

Feb 1, 1993·Cancer Genetics and Cytogenetics·O MorY Shiloh
Jun 1, 2005·Cancer Treatment Reviews·Joseph M KaminskiJeffrey Brousal
Aug 5, 1998·Cancer Genetics and Cytogenetics·W ZoliA Gasperi-Campani
Mar 5, 1998·International Journal of Radiation Oncology, Biology, Physics·M HareyamaK Morita
Jul 3, 2013·Nature Reviews. Drug Discovery·Everett J ModingDavid G Kirsch
Apr 9, 2008·Journal of Immunotherapy·Seagal Teitz-TennenbaumAlfred E Chang
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Jun 17, 2014·Laboratory Investigation; a Journal of Technical Methods and Pathology·Sergey A KaliberovDavid T Curiel
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Dec 1, 2006·Veterinary and Comparative Oncology·D H Thamm
Jul 2, 2010·Clinical and Translational Science·Julia RotowJames W Hodge
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Jul 6, 2014·Radiation Research·Robert E RosesBrian J Czerniecki
Feb 15, 2015·Cancer Letters·Gabriele MulthoffDaniela Schilling
Dec 1, 1993·Scandinavian Journal of Clinical and Laboratory Investigation·J CarlB Nørgaard-Pedersen
Jan 18, 2018·Cancer Immunology, Immunotherapy : CII·Lucas BaslerStephan M Huber
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Jun 19, 2001·International Journal of Cancer. Journal International Du Cancer·S Kunala, R M Macklis
Jun 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mala ChakrabortyJames W Hodge
Dec 5, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chao-Yi WuT-C Wu
Jul 5, 2019·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Bodo E Lippitz, Robert A Harris

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