PMID: 11927315Apr 3, 2002Paper

Effect of radical prostatectomy on urethral blood flow

Urology
H JohnD Hauri

Abstract

To study the effect of radical retropubic prostatectomy on urethral microcirculatory blood perfusion and urinary continence. Urinary stress incontinence after radical prostatectomy depends mainly on intrinsic distal sphincter integrity. Urethral laser Doppler flowmetry was performed in 37 patients before and in 23 patients after (mean 15 months, range 2 to 23) radical prostatectomy for clinically localized prostate cancer. An endoscopic laser Doppler flow probe with a diameter of 1.8 mm was introduced through the working channel of a cystoscope and gently applied to the urethral mucosa at an intravesical pressure of 30 cm H(2)O. Blood flow was expressed simultaneously as a digital reading on the flowmeter (milliliters blood per minute per 100 gram tissue). The mean arterial blood pressure was monitored noninvasively. The Mann-Whitney U test was used for statistical analysis. Membranous urethral blood flow significantly decreased after radical prostatectomy from 18.8 +/- 7.9 mL/min per 100 gram tissue to 11.9 +/- 7.7 mL/min per 100 gram tissue (P = 0.04). However, the difference in the blood flow did not statistically differentiate continent patients from patients with urinary stress incontinence (P = 0.47). No correlation betwe...Continue Reading

References

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Citations

Apr 7, 2004·The Tohoku Journal of Experimental Medicine·Yoshihiro OnoHidetoshi Yamanaka
Jan 14, 2004·International Journal of Andrology·Yoshihiro OnoHidetoshi Yamanaka
May 15, 2004·BJU International·C D A HerndonA J Casale
Sep 14, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Giorgio GandagliaAlberto Briganti
Feb 16, 2013·The Journal of Urology·Catherine R HarrisPeter R Carroll
Mar 8, 2019·Neurourology and Urodynamics·Florian GerbaudPhilippe Manceau
Jan 24, 2019·Therapeutic Advances in Urology·Carlos ArroyoAshutosh K Tewari
Apr 17, 2020·Minerva urologica e nefrologica = The Italian journal of urology and nephrology·Jae W ChungEun S Yoo

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