Effect of radiochemotherapy on T2* MRI in HNSCC and its relation to FMISO PET derived hypoxia and FDG PET

Radiation Oncology
Nicole E WiedenmannAnca L Grosu

Abstract

To assess the effect of radiochemotherapy (RCT) on proposed tumour hypoxia marker transverse relaxation time (T2*) and to analyse the relation between T2* and 18F-misonidazole PET/CT (FMISO-PET) and 18F-fluorodeoxyglucose PET/CT (FDG-PET). Ten patients undergoing definitive RCT for squamous cell head-and-neck cancer (HNSCC) received repeat FMISO- and 3 Tesla T2*-weighted MRI at weeks 0, 2 and 5 during treatment and FDG-PET at baseline. Gross tumour volumes (GTV) of tumour (T), lymph nodes (LN) and hypoxic subvolumes (HSV, based on FMISO-PET) and complementary non-hypoxic subvolumes (nonHSV) were generated. Mean values for T2* and SUVmean FDG were determined. During RCT, marked reduction of tumour hypoxia on FMISO-PET was observed (T, LN), while mean T2* did not change significantly. At baseline, mean T2* values within HSV-T (15 ± 5 ms) were smaller compared to nonHSV-T (18 ± 3 ms; p = 0.051), whereas FDG SUVmean (12 ± 6) was significantly higher for HSV-T (12 ± 6) than for nonHSV-T (6 ± 3; p = 0.026) and higher for HSV-LN (10 ± 4) than for nonHSV-LN (5 ± 2; p ≤ 0.011). Correlation between FMISO PET and FDG PET was higher than between FMSIO PET and T2* (R2 for GTV-T (FMISO/FDG) = 0.81, R2 for GTV-T (FMISO/T2*) = 0.32). Marked re...Continue Reading

References

Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S OgawaD W Tank
Jun 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·F PrielmeierJ Frahm
May 20, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C M WackerL R Schad
Jul 31, 2001·Journal of Magnetic Resonance Imaging : JMRI·N J TaylorJ R Griffiths
Sep 27, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Joseph G RajendranKenneth A Krohn
Oct 18, 2006·European Radiology·Anwar R PadhaniMarkus Alber
Sep 17, 2009·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Govind B ChavhanE Mark Haacke
Oct 2, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Daniel ZipsMichael Baumann
Jul 3, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Rami R HallacRalph P Mason
Jul 16, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Martin-Immanuel BittnerAnca-Ligia Grosu
Feb 5, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Sean CarlinSally-Ann Ricketts
Mar 19, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Christina SchützeBettina Beuthien-Baumann
Jun 2, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Markus Alber, Daniela Thorwarth
Dec 11, 2014·International Journal of Radiation Oncology, Biology, Physics·Sarah G J A PeetersPhilippe Lambin
Oct 4, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Nicole E WiedenmannAnca L Grosu
Jan 23, 2016·Journal of Magnetic Resonance Imaging : JMRI·Rafal PanekMartin O Leach
Feb 14, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Sara LeibfarthDaniela Thorwarth
Feb 12, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Milan GrkovskiJohn L Humm
Mar 21, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rafal PanekKate L Newbold
Aug 15, 2017·NMR in Biomedicine·Christine PreibischStefan Förster
Aug 28, 2017·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Steffen LöckMichael Baumann
Sep 5, 2017·Zeitschrift für medizinische Physik·Daniela Thorwarth
Apr 22, 2018·International Journal of Radiation Oncology, Biology, Physics·Ismini C MaintaRaymond Miralbell

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Citations

Apr 23, 2020·Radiation Oncology·M UnterrainerC Belka
Dec 1, 2020·Nuclear Medicine Communications·Anthime FlausNathalie Prévot
Aug 30, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Nils H NicolayAnca-L Grosu
Mar 24, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Alexander RühleNils H Nicolay
May 12, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Daniela ThorwarthDaniel Zips
Jun 17, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Nicole WiedenmannNils H Nicolay
Jul 15, 2021·Nuklearmedizin. Nuclear Medicine·Constantin LapaUNKNOWN “Arbeitsgemeinschaft Nuklearmedizin und Strahlentherapie der DEGRO und DGN”
Jul 15, 2021·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Constantin LapaUNKNOWN Arbeitsgemeinschaft Nuklearmedizin und Strahlentherapie der DEGRO und DGN
Nov 1, 2020·Clinical Oncology : a Journal of the Royal College of Radiologists·C PatersonC N Rumley

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SigmaPlot
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