Effect of radiographic contrast media on histamine release from human mast cells and basophils

The British Journal of Radiology
P T Peachell, S K Morcos

Abstract

Radiographic contrast media (RCM) cause histamine-dependent allergic-like reactions. The direct effects of diatrizoate (high osmolar ionic monomer), ioxaglate (low osmolar ionic dimer), iopromide (low osmolar non ionic monomer) and iotrolan (iso-osmolar non ionic dimer) at the concentration of 200 mgI ml-1 (60 min exposure) on the release of histamine from human basophils, human lung mast cells (HLMC), and human skin mast cells (HSMC) were investigated. Diatrizoate induced 48 +/- 4% histamine release in basophils, 15 +/- 3% in HLMC and 25 +/- 6% in HSMC. The remaining RCM were relatively ineffective activators of histamine release in both HLMC and HSMC (ioxaglate 4 +/- 1% and 4 +/- 1%, iopromide 5 +/- 1% and 7 +/- 2%, iotrolan 7 +/- 2% and 10 +/- 3%, respectively). Both iotrolan and ioxaglate were effective in basophils inducing 21 +/- 3% and 24 +/- 6% histamine release, respectively, whereas iopromide was relatively ineffective (7 +/- 4%). Diatrizoate induced histamine release from all three cell types with optimal levels of histamine release after a 2-4 h incubation although significant levels occurred within 15 min. Dose-dependent histamine release from HLMC occurred in all four types of RCM, the largest response (37 +/- 3%)...Continue Reading

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Citations

May 24, 2003·The British Journal of Radiology·S K Morcos
Oct 11, 2012·Polish journal of radiology·Tomasz Kun, Lucjusz Jakubowski
Nov 17, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Peter Bradding, Greer Arthur
Aug 22, 2003·British Journal of Haematology·Peter ValentDean D Metcalfe
Apr 24, 2010·Fundamental & Clinical Pharmacology·Ingrid BöhmHans H Schild
Apr 12, 2005·Journal of Pharmacological Sciences·Yoshinori ItohRyozo Oishi
Apr 13, 2004·Journal of the American Veterinary Medical Association·Cornelia I GunkelEric A Ferrell
Feb 4, 2006·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Marc J Meth, Howard I Maibach
Aug 10, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Bernard Yu-Hor ThongRik Schrijvers

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