Effect of radiotherapy on anorectal function in patients with cervical cancer

Diseases of the Colon and Rectum
T IwamotoM Tanaka

Abstract

The acute and long-term effects of pelvic radiation on defecation were studied. Anorectal function was assessed based on manometry and subjective symptoms in 31 patients with cervical cancer treated by radiotherapy alone. Sixteen of 31 patients were examined periodically before, during, and after radiotherapy (early group). Fifteen others were examined more than six months after completion of radiotherapy (late group). One-third of patients in both groups had symptoms, mainly diarrhea and increased stool frequency. Patients in the late group also suffered from disturbed gas-stool discrimination, urgency, a sense of residual stool, and soiling. Anal canal resting pressure was significantly higher after radiotherapy (47 +/- 15.5 mmHg) than before radiotherapy (36.3 +/- 12.5 mmHg; P < 0.05). The maximum tolerable volume decreased with radiation, from 163.3 +/- 45 before to 119.2 +/- 41.4 ml during, 112.7 +/- 36.6 ml immediately after, and 94.6 +/- 34.4 ml in the late group (P < 0.01). Rectal compliance also decreased over time and was lower in the early group (before, 5.7 +/- 1.3 ml/mmHg; P < 0.01; during, 4.6 +/- 2.2 ml/mmHg, P < 0.01; after, 3.7 +/- 1.4 ml/mmHg; P < 0.05) than the late group (2.1 +/- 1.5 ml/mmHg) and lower befor...Continue Reading

References

Apr 1, 1979·American Journal of Surgery·J C Russell, J P Welch
May 1, 1992·Digestive Diseases and Sciences·M F OttersonM B Lee
Feb 1, 1986·American Journal of Surgery·S W JaoL L Gunderson
Apr 1, 1985·Annals of Surgery·P A HatcherA N Smith
Nov 1, 1985·Archives of Surgery·L MorgensternN B Friedman
Nov 1, 1971·American Journal of Obstetrics and Gynecology·D A BuchlerW F Carr
Dec 1, 1981·Annals of Surgery·P F AnselineF L Weakley
Sep 1, 1994·Diseases of the Colon and Rectum·E H BirnbaumJ W Fleshman

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Citations

Mar 3, 2001·Diseases of the Colon and Rectum·K KroghT S Laurberg
Nov 23, 2000·Diseases of the Colon and Rectum·S D Wexner, N A Rotholtz
May 15, 2007·International Journal of Colorectal Disease·Alexander P PietschErnst Klar
Jun 4, 2005·Diseases of the Colon and Rectum·Lilli LundbySoren Laurberg
Nov 18, 2005·Diseases of the Colon and Rectum·Jit F LimPeter Gibbs
Jul 31, 2007·Diseases of the Colon and Rectum·Sven PetersenMarco Sailer
Apr 16, 2005·Clinical Oncology : a Journal of the Royal College of Radiologists·S Badvie, H J N Andreyev
Jun 2, 2005·International Journal of Radiation Oncology, Biology, Physics·H Jervoise N AndreyevDiana Tait
Oct 12, 2002·Journal of the American College of Surgeons·Anil K SoodSatish S C Rao
Aug 8, 2001·The British Journal of Surgery·D HayneP B Boulos
Feb 1, 2005·Clinics in Colon and Rectal Surgery·Harry T Papaconstantinou
Mar 20, 2012·Diseases of the Colon and Rectum·Bruno LorenziNeil J Mc C Mortensen
Nov 18, 2003·Alimentary Pharmacology & Therapeutics·B GamiH J N Andreyev
May 26, 2001·Clinical Oncology : a Journal of the Royal College of Radiologists·D HayneH Payne
Mar 16, 2013·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Alessandra Ferreira de NoronhaAgnaldo L Silva-Filho
Sep 10, 2005·Clinical Oncology : a Journal of the Royal College of Radiologists·S Putta, H J N Andreyev
Dec 17, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Marloes DerksMoniek M Ter Kuile
Jul 29, 2008·Current Opinion in Supportive and Palliative Care·Martin Hauer-JensenJames W Denham
Mar 20, 2010·The Cochrane Database of Systematic Reviews·Ludy LutgensPhilippe Lambin
Sep 24, 2021·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Runchida SuvannasarnKittipat Charoenkwan

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