Effect of ramipril in reducing sudden deaths and nonfatal cardiac arrests in high-risk individuals without heart failure or left ventricular dysfunction

Circulation
Koon K TeoHOPE Investigators

Abstract

ACE inhibitor therapy reduces the risk of cardiovascular death, myocardial infarction, stroke, hospitalization for heart failure, and need for revascularization in high-risk patients with clinical heart failure, overt left ventricular systolic dysfunction, or vascular disease. In patients with clinical heart failure or overt left ventricular systolic dysfunction, ACE inhibitor therapy also reduces the risk of sudden or arrhythmia-related cardiac death. The objective of this study was to assess the effect of the ACE inhibitor ramipril on sudden unexpected death or resuscitated cardiac arrest among the 9297 individuals without clinical heart failure or overt left ventricular dysfunction enrolled in the Heart Outcomes Prevention Evaluation (HOPE) trial. During the median follow-up of 4.5 years, the composite outcome of unexpected death, documented arrhythmic death, or resuscitated cardiac arrest was reduced by 21% in patients randomized to ramipril therapy compared with those randomized to placebo. There were 155 (3.3%) composite outcome events in patients randomized to ramipril therapy compared with 195 (4.2%) such events in patients randomized to placebo (RR 0.79, 95% CI 0.64 to 0.98, P=0.028). There were trends toward reduction...Continue Reading

References

Aug 1, 1991·The New England Journal of Medicine·UNKNOWN SOLVD InvestigatorsJay N Cohn
Mar 1, 1986·Postgraduate Medical Journal·A J BayerM S Pathy
Jan 20, 2000·The New England Journal of Medicine·UNKNOWN Heart Outcomes Prevention Evaluation Study InvestigatorsG Dagenais
Jan 20, 2000·The New England Journal of Medicine·UNKNOWN Heart Outcomes Prevention Evaluation Study InvestigatorsP Sleight
Sep 19, 2003·Lancet·K M Fox, UNKNOWN EURopean trial On reduction of cardiac events with Perindopril in stable coronary Artery disease Investigators

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Citations

Mar 8, 2008·Current Treatment Options in Cardiovascular Medicine·Kapil KumarRichard L Verrier
Nov 3, 2005·Nature Clinical Practice. Cardiovascular Medicine·Lars Kjøller-Hansen
Jun 22, 2007·Clinical and Experimental Pharmacology & Physiology·Jiang-Hua ZhongZhen Yao
Mar 6, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Vijaykumar S KasiSamuel C Dudley
Apr 6, 2013·Circulation. Arrhythmia and Electrophysiology·Ali A SovariSamuel C Dudley
Aug 1, 2013·Vascular Health and Risk Management·Carlos M FerrarioFeride Frech-Tamas
Oct 9, 2007·Journal of Hypertension·Nimit C ShahAllan D Struthers
Aug 11, 2006·Current Opinion in Cardiology·Adnan Siddiqui, Peter R Kowey
Aug 23, 2005·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·M J McQueenS Yusuf
Nov 26, 2015·Journal of Cardiac Failure·Paul A Heidenreich
Sep 1, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Zian H Tseng
Jun 10, 2008·Cardiology Clinics·L Brent Mitchell
Jul 9, 2010·Fundamental & Clinical Pharmacology·Giuseppe BorianiAngelo Branzi
Mar 4, 2008·The American Journal of Cardiology·Judith HsiaUNKNOWN PEACE Investigators
Apr 18, 2006·The American Journal of Cardiology·Joseph J GermanoMark E Josephson
Nov 19, 2011·Journal of the American College of Cardiology·Ali A SovariSamuel C Dudley
Aug 5, 2008·The Cochrane Database of Systematic Reviews·Goran BjelakovicChristian Gluud
Mar 16, 2012·The Cochrane Database of Systematic Reviews·Goran BjelakovicChristian Gluud
May 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Sergio RichterStefan H Hohnloser
Jan 16, 2020·Journal of Human Hypertension·Elias SanidasJohn Barbetseas
May 10, 2017·Herzschrittmachertherapie & Elektrophysiologie·Benjamin Jong-Ming Pang, Martin Stephen Green

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