Effect of random seed placement error in permanent transperineal prostate seed implant

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Martin BuesIrving D Kaplan

Abstract

Random seed placement error may adversely effect dose distribution in transperineal prostate seed implants. In this study, we investigated the extent to which individual seed activity influences dose-distribution degradation due to random seed placement error. Separate initial treatment plans were prepared for three prostate sizes, 27.3, 43.2 and 48.9 cc, using 0.35, 0.55 and 0.75 mCi iodine-125 seeds. All stated activities are understood to be apparent activities. The combinations produced a total of nine treatment plans. Each initial treatment plan was subjected to 1000 stochastic three-dimensional Gaussian perturbations of seed location, with a standard deviation of 4mm for a total of 9000 treatment plans. The resulting plans were evaluated for target coverage and urethra involvement. Satisfactory initial treatment plans were prepared for all prostate sizes and seed activities. All 9000 perturbed treatment plans showed acceptable target coverage under the D90/90 criterion. Some of the perturbed plans for the 27.3 and 43.2 cc prostates with 0.55 and 0.75 mCi seeds failed the V100/90 criterion. Some of the randomly perturbed seed distributions showed significantly increased doses to the urethra relative to the unperturbed trea...Continue Reading

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Citations

Feb 16, 2010·Brachytherapy·Gregory S MerrickJonathan Khanjian
Nov 27, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Michiel R van den BoschMarinus A Moerland
May 6, 2015·International Journal of Radiation Oncology, Biology, Physics·Bashar Al-QaisiehStephen Langley
Oct 4, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Christine Haie-MederRichard Pötter
Dec 25, 2015·Journal of Applied Clinical Medical Physics·Sarah L ElliottJeremy L Millar

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