Effect of ranitidine and indomethacin on nocturnal gastric acidity in normal subjects

Alimentary Pharmacology & Therapeutics
R P WaltM J Langman

Abstract

To assess the effect of indomethacin on gastric acidity and to identify a potential pharmacodynamic interaction between indomethacin and ranitidine, we measured nocturnal acidity on half-hourly aliquots of gastric contents from 10 volunteers on the seventh day of four dosing regimens given in a randomized double-blind manner. These were indomethacin (50 mg t.d.s.) and ranitidine (300 mg in the evening) together or alone with matching placebos. Median nocturnal acidity on placebo was 41.7 mmol/L (range 67.6-25.1 mmol/L) and was 39.8 mmol/L (63.1-24.0 mmol/L) on indomethacin (N.S.). During ranitidine dosing it was 0.4 mmol/L (21.3-0.0 mmol/L) without and 0.8 mmol/L (43.7-0.0 mmol/L) with concurrent indomethacin, representing 99 and 98% decreases in gastric acidity (P less than 0.01) compared with placebo. Indomethacin did not increase overnight gastric acidity and did not influence the suppression of acidity produced by ranitidine. It is unlikely that the ulcerogenic potential of indomethacin is explicable by an effect on gastric acidity.

References

Aug 1, 1977·British Journal of Pharmacology·A Bennett, B P Curwain
Mar 1, 1986·Lancet·K SomervilleM Langman
Jan 17, 1987·British Medical Journal·A C RossiG A Faich
Sep 1, 1988·Annals of Internal Medicine·M R GriffinW Schaffner
Sep 1, 1973·The American Journal of Physiology·D K Kasbekar
Jun 1, 1964·Gut·A LYNCHG W MILTON

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Citations

Apr 1, 1994·Alimentary Pharmacology & Therapeutics·C J Hawkey

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