PMID: 9533060Apr 9, 1998Paper

Effect of ranitidine on the pharmacokinetics of orally administered eprosartan, an angiotensin II antagonist, in healthy male volunteers

The Annals of Pharmacotherapy
D M TeneroD K Jorkasky

Abstract

To assess the effect of ranitidine on the pharmacokinetics of eprosartan in healthy male volunteers. Single-center, randomized, open-label, two-period, period-balanced, crossover study. Seventeen healthy men aged 19 to 43 years. In each period (separated by a > or = 7 d washout), subjects received a single 400-mg oral dose of eprosartan alone, or a single oral dose of eprosartan 400 mg and ranitidine 150 mg on day 4 after 3 days of ranitidine 150 mg twice daily. Serial pharmacokinetic samples were obtained for up to 24 hours following eprosartan dosing. Plasma and urine eprosartan concentrations during each treatment session. Eprosartan maximum concentration (Cmax), the AUC from time-zero to the last quantifiable concentration (AUC0-t), and renal clearance (Cl(r)) values were approximately 7%, 11%, and 4% lower, respectively, when administered with ranitidine compared with eprosartan alone. The 95% CIs for the ratio of eprosartan plus ranitidine compared with eprosartan alone were 0.81 to 1.07, 0.77 to 1.03, and 0.64 to 1.43, for Cmax, AUC0-t, and Cl(r), respectively, indicating no statistically significant difference between regimens. Repeated doses of ranitidine did not have a marked effect on the single-dose pharmacokinetics...Continue Reading

Citations

Jan 9, 2003·Expert Opinion on Pharmacotherapy·Luis Ruilope, Bodo Jäger
Feb 16, 2005·Expert Opinion on Drug Safety·Steffen BöhlerWilhelm Kirch

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