Effect of rat-to-mouse bioartificial pancreas xenotransplantation on diabetic renal damage and survival

Pancreas
Naoaki SakataKazutomo Inoue

Abstract

Diabetic nephropathy is a life-threatening complication of diabetes mellitus. Bioartificial pancreas transplantation is becoming a therapeutic option for diabetes mellitus as it protects both allogeneic and xenogeneic islets from the host immune system. This study was undertaken to determine the effectiveness of bioartificial pancreas transplantation to improve or prevent diabetic renal damage. Approximately 800 rat islets were macroencapsulated in polyvinyl alcohol gel and then transplanted into the peritoneal cavity of diabetic mice (transplantation group [Tx group]). Diabetic mice transplanted with a capsule without islets served as a sham operation group. After transplantation, the following data were collected: survival, body weight, blood glucose, blood urea nitrogen, serum creatinine levels, urinalysis, water intake, and histological changes in the kidney. There was a significant improvement in survival, blood glucose, blood urea nitrogen, and creatinine in the Tx group compared with the sham operation group. No remarkable changes were seen in urinary parameters between the 2 groups, and there was also no significant difference in water intake. Histological examination revealed that mesangial matrix expansion was decreas...Continue Reading

References

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Jun 3, 2004·Biomaterials·Meirigeng QiKazutomo Inoue

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Citations

Oct 7, 2008·Journal of Hepato-biliary-pancreatic Surgery·Naoaki SakataMichiaki Unno
Jan 5, 2012·World Journal of Gastroenterology : WJG·Naoaki SakataMichiaki Unno
Feb 13, 2010·Biomaterials·Zhi QiShoichiro Sumi
Feb 23, 2010·Biochemical and Biophysical Research Communications·Kai-Chiang YangShoichiro Sumi
Jun 14, 2006·Xenotransplantation·Reto M Baertschiger, Leo H Buhler
Jul 1, 2010·Journal of Hepato-biliary-pancreatic Sciences·Shoichiro Sumi
Apr 18, 2015·Journal of Diabetes and Its Complications·Hae Kyung Yang, Kun-Ho Yoon
Mar 1, 2012·World Journal of Gastrointestinal Pathophysiology·Naoaki SakataMichiaki Unno
May 8, 2018·Xenotransplantation·Kate E SmithKlearchos K Papas

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