PMID: 9165309Jan 1, 1997Paper

Effect of reactive oxygen species on the elastin mRNA expression in cultured human dermal fibroblasts

Free Radical Biology & Medicine
Y KawaguchiJ Asai

Abstract

The effects of ultraviolet A (UVA) and reactive oxygen species (ROS), generated by a xanthine and xanthine oxidase (XOD) system, on the mRNA expression of elastin, were investigated using cultured human dermal fibroblasts. Total RNA was isolated and subjected to Northern blot analysis using synthesized 530 base cDNA probe for elastin with primers derived from exon 10 and 1 of human elastin. UVA irradiation did not affect elastin mRNA expression. In contrast, ROS resulted in a dose-related increase in the level of elastin mRNA up to 1.8-fold in cultured human dermal fibroblasts. Catalase, used as scavenger, essentially prevented the ROS induced alterations in elastin mRNA levels. These results suggest that ROS produced in the dermis may contribute to elastin deposition observed in photoaging skin.

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Citations

Jan 25, 2012·European Journal of Applied Physiology·H B VierckA Patzelt
Mar 1, 2002·Mechanisms of Ageing and Development·Gail Jenkins
Jun 1, 2000·Experimental Gerontology·K Scharffetter-KochanekM Wlaschek
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Dec 3, 2014·Clinics in Dermatology·Cemal BilaçSerap Öztürkcan
Aug 25, 2005·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Susanne Grether-BeckKarin Scharffetter-Kochanek
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May 22, 2021·Archives of Biochemistry and Biophysics·Jiechun ZhuGuangdong Yang

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