PMID: 8960705Nov 1, 1996Paper

Effect of rearing temperature on perirenal adipose tissue development and thermoregulation following methimazole treatment of postnatal lambs

Experimental Physiology
M E SymondsM A Lomax

Abstract

This study examined the effect of ambient temperature on perirenal adipose tissue development and thermoregulation over the first month of postnatal life in lambs treated with a drug that reduces thyroid hormone synthesis (methimazole; at a dose of 50 mg day-1 (kg body weight)-1). Twin lambs were hand-reared at a fixed level of nutrition in either a warm (WR; 25 degrees C) or cool (CR; 10-15 degrees C) ambient temperature. Oxygen consumption, heart rate and colonic temperature were measured during non-rapid eye movement sleep in different ambient temperatures (6, 15, 25 and 34-36 degrees C) at 7, 14 and 28 days of age. Plasma thyroid hormone concentrations decreased with postnatal age and were higher in CR than in WR lambs. All lambs increased plasma thyroid hormone concentrations and O2 consumption during cold exposure but this was associated with a mean increase in colonic temperature in WR lambs at 7 or 28 days. Colonic temperature increased with the onset of panting at all ages when lambs were exposed to 34-36 degrees C, a response that was greatest at 28 days in CR lambs. An increase in colonic temperature with age was observed in CR but not WR lambs. Heart rate declined with age only in the WR group. At 8 and 29 days ther...Continue Reading

Citations

Nov 28, 2013·Scientifica·Michael E Symonds
Jun 28, 2014·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Myrte MerkesteinDyan Sellayah
Dec 18, 2010·Progress in Biophysics and Molecular Biology·Michael E SymondsMichael A Lomax
May 15, 2015·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·R OelkrugM Jastroch
May 24, 2018·The Journal of Endocrinology·Michael E SymondsHelen Budge
May 14, 2019·The Journal of Clinical Investigation·Christy M Gliniak, Philipp E Scherer

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