PMID: 7035821Jan 1, 1981Paper

Effect of recB21, uvrD3, lexA101 and recF143 mutations on ultraviolet radiation sensitivity and genetic recombination in delta uvrB strains of Escherichia coli K-12

Molecular & General Genetics : MGG
T C Wang, K C Smith

Abstract

The interaction of the recB21, uvrD3, lexA101, and recF143 mutations on UV radiation sensitization and genetic recombination was studied in isogenic strains containing all possible combinations of these mutations in a delta uvrB genetic background. The relative UV radiation sensitivities of the multiply mutant strains in the delta uvrB background were: recF recB lexA greater than recF recB uvrD lexA, recF recB uvrD greater than recA greater than recF uvrD lexA greater than recF recB, recF uvrD greater than recF lexA greater than recB uvrD lexA greater than recB uvrD greater than recB lexA, lexA uvrD greater than recB greater than lexA, uvrD greater than recF; three of these strains were more UV radiation sensitive than the uvrB recA strain. There was no correlation between the degree of radiation sensitivity and the degree of deficiency in genetic recombination. An analysis of the survival curves revealed that the recF mutation interacts synergistically with the recB, uvrD, and lexA mutations in UV radiation sensitization, while the recB, uvrD, and lexA mutations appear to interact additively with each other. We interpret these data to suggest that there are two major independent pathways for postreplication repair; one is depe...Continue Reading

References

Jan 1, 1979·Cold Spring Harbor Symposia on Quantitative Biology·J RosamondS Linn
Oct 24, 1977·Molecular & General Genetics : MGG·R H Rothman, A J Clark
Oct 24, 1977·Molecular & General Genetics : MGG·R H Rothman, A J Clark
Nov 29, 1977·Molecular & General Genetics : MGG·B F Johnson
Dec 1, 1975·Molecular & General Genetics : MGG·A K Ganesan, P C Seawell
Sep 12, 1973·Molecular & General Genetics : MGG·M Brendel, R H Haynes
May 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·A Braun, L Grossman
Oct 1, 1967·Journal of Cellular Physiology·A J Clark
Jan 1, 1968·Annual Review of Biochemistry·P Howard-Flanders
May 3, 1968·Molecular & General Genetics : MGG·H OgawaJ Tomizawa
Oct 14, 1971·Journal of Molecular Biology·W D RuppP Howard-Flanders
Aug 1, 1965·Journal of Bacteriology·K A STACEY, E SIMSON

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Citations

Jan 1, 1990·Journal of Basic Microbiology·D J SavicT Kostic
Sep 1, 1987·Journal of Photochemistry and Photobiology. B, Biology·K C SmithR C Sharma
Mar 19, 2002·Journal of Photochemistry and Photobiology. B, Biology·S M D Barros, J P Siqueira-Junior
Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·Q PangI Rajagopal
Aug 2, 2008·PLoS Genetics·Stéphanie MarsinJ Pablo Radicella
Oct 14, 2009·Molecular Biology Reports·Yen-Yu ChenTzu-Chien V Wang
Nov 1, 1990·Journal of Bacteriology·T J Griffin, R D Kolodner
Nov 25, 2000·Molecular Cell·G A Cromie, D R Leach
May 15, 1992·Biochemical and Biophysical Research Communications·T C Wang, S H Chen

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