PMID: 8938563Nov 1, 1996Paper

Effect of recombinant bovine interleukin-1 beta in normal calves and in calves infected with bovine herpesvirus type 1

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
A Van KesselL A Babiuk

Abstract

Bovine herpesvirus-1 (BHV-1) is an important pathogen of respiratory infections in cattle. Its continuing importance lies in its ability to predispose infected hosts to bacterial infections. In this present study, we determined whether the immunoregulatory effects induced by interleukin-1 (IL-1) could stimulate appropriate host defense mechanisms to influence the course of BHV-1 infection in cattle. We first evaluated the effect of different doses (10-1000 ng/kg) of IL-1 in normal cattle. A single administration of IL-1 was able to induce a dose-dependent increase in polymorphonuclear (PMN) cells as well as monocytes in peripheral blood. The number of CD3+ lymphocytes and gamma/delta T cells in peripheral circulation decreased transiently in a dose-dependent manner. In the disease model, the effect of IL-1 administration (300 ng/kg) 24 h before, at the time of, and 24 h after the BHV-1 challenge was assessed. As a single therapeutic modality, IL-1 did not significantly reduce the establishment or progression of BHV-1-induced disease. Nevertheless, our results demonstrated that the significant modulation of diverse immune parameters did not exacerbate disease. Thus, the use of IL-1 as an adjunct therapy or as a vaccine adjuvant ...Continue Reading

References

Jun 1, 1992·Immunological Reviews·C A Dinarello
Jan 1, 1991·International Journal of Immunopharmacology·M Denis
May 1, 1991·Infection and Immunity·Y F ZhanC Cheers
May 1, 1985·The Journal of Infectious Diseases·H Bielefeldt Ohmann, L A Babiuk
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J W van der MeerC A Dinarello
Sep 1, 1987·Infection and Immunity·C J Czuprynski, J F Brown
Jun 1, 1993·Veterinary Immunology and Immunopathology·D N ReddyF Blecha

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Citations

Mar 16, 2000·Developmental and Comparative Immunology·M A JohnsonJ W Lowenthal
Oct 22, 2008·Veterinary Microbiology·J C Detilleux
Jul 28, 2004·Research in Veterinary Science·Ahmed M Alluwaimi

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