Effect of recombinant granulocyte colony-stimulating factor on erythropoiesis in the human fetus and neonate

Pediatric Research
D A CalhounR D Christensen

Abstract

Administration of large doses of recombinant granulocyte colony-stimulating factor (rG-CSF) to mice results in diminished erythropoiesis. Hyporegenerative anemia does not occur in adult humans as a consequence of treatment with rG-CSF, but it is not clear whether this will be a problem in neonates. Because rG-CSF is currently being tested as a treatment for neutropenia in neonates, we assessed the possibility that such treatment will diminish their erythropoiesis. To do this, we added rG-CSF, in vitro, to clonogenic cultures of hematopoietic progenitors obtained from the bone marrow and liver of seven human fetuses and from the umbilical cord blood of five term and five preterm infants. The range of rG-CSF concentrations tested (0.1-10.0 ng/mL) included the peak concentrations measured in the blood of neonates receiving rG-CSF treatment on experimental protocols. Inclusion of rG-CSF in the cultures did not diminish clonal maturation of fetal erythroid (erythroid colony-forming and burst-forming unit) progenitors, nor did it reduce the number of normoblasts generated per erythroid progenitor cell colony. On the basis of these studies we predict that administration of rG-CSF to neonates will not result in down-modulation of eryth...Continue Reading

References

Feb 1, 1992·American Journal of Hematology·R D Christensen, G Rothstein
Apr 1, 1989·The Journal of Pediatrics·J M Koenig, R D Christensen
Jul 20, 1989·The New England Journal of Medicine·J W EschbachJ W Adamson
Jun 1, 1987·The Journal of Clinical Investigation·C A Sieff
Jan 1, 1988·Developmental Biology·A R Migliaccio, G Migliaccio
Jun 5, 1987·Science·S C Clark, R Kamen
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·N A Nicola, D Metcalf
Apr 15, 1994·Annals of the New York Academy of Sciences·W NijhofM Loeffler
Jul 1, 1994·Archives of Pediatrics & Adolescent Medicine·J C MurrayM E Wearden
Mar 1, 1995·The Journal of Pediatrics·E F La GammaP Kocherlakota

❮ Previous
Next ❯

Citations

Sep 25, 2001·American Journal of Obstetrics and Gynecology·D V SurbekW Holzgreve
Jun 14, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paola PapaldoFrancesco Cognetti
Sep 15, 2000·Clinics in Perinatology·R D ChristensenL M Rimsza

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.