PMID: 9436556Jan 22, 1998Paper

Effect of recombinant human erythropoietin on transfusion risk in coronary bypass patients

The Annals of Thoracic Surgery
M N D'AmbraR I Abels

Abstract

Patients having a cardiac operation frequently require allogeneic blood transfusions despite surgical blood-conservation techniques. Recombinant human erythropoietin (Epoetin alfa) may augment this conservation by stimulating erythropoiesis. The safety and efficacy of perioperative use of Epoetin alfa to reduce the need of allogeneic transfusion was studied. A multicenter double-blind, placebo-controlled, parallel-group study involved 182 patients having coronary artery bypass grafting and randomized to receive Epoetin alfa (300 or 150 IU/kg) or placebo subcutaneously for 5 days before, on the day of, and for 2 days after operation. Perioperative Epoetin alfa resulted in greater increases in baseline to preoperative hemoglobin levels and hematocrit (300 IU/kg) and in presurgery to postsurgical day 1 reticulocyte counts versus placebo (p < or = 0.05). However, there was no significant difference in transfusion requirements. Incidences of adverse events were similar in all study groups. Lower incidences of allogeneic blood exposure were observed in both Epoetin alfa-treated groups; however, the differences between all treatment groups were not significant. This was probably due to the relatively short 5-day preoperative course of...Continue Reading

References

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Citations

Jun 1, 2005·Anesthesiology Clinics of North America·Aryeh Shander, Tanuja S Rijhwani
Sep 19, 2002·American Journal of Therapeutics·Edward Crosby
Feb 18, 2014·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·C David Mazer
May 28, 2013·Lancet·Donat R Spahn, Lawrence T Goodnough
Apr 18, 2013·Best Practice & Research. Clinical Anaesthesiology·Lawrence Tim Goodnough, Aryeh Shander
Mar 20, 2009·The American Journal of the Medical Sciences·David M Spiegel
Nov 29, 2005·Journal of Cardiac Surgery·Chad E LewisAmy M Engel
Sep 11, 2013·Transfusion·Aryeh ShanderDavid Henry
May 9, 2014·Transfusion·Sharon McCartneySteven Hill
Oct 6, 2005·Journal of Cardiothoracic and Vascular Anesthesia·Wulf DietrichKarin Berger
Sep 1, 2015·Revista española de anestesiología y reanimación·G J Yanes Vidal
Jun 21, 2012·The Journal of Thoracic and Cardiovascular Surgery·Gabriel LoorEugene H Blackstone
Oct 3, 2001·The Journal of Thoracic and Cardiovascular Surgery·L YazicioğluH Akalin
Dec 15, 2015·Seminars in Cardiothoracic and Vascular Anesthesia·Robin Varghese, Jeffrey Jhang
Mar 1, 2005·Seminars in Cardiothoracic and Vascular Anesthesia·Aryeh ShanderTanuja S Rijhwani
Mar 30, 2019·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Tiffanie KeiGregory M T Hare
Jan 26, 1999·Clinical Orthopaedics and Related Research·L T Goodnough, T G Monk
Jan 20, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·L T Goodnough, G J Despotis
Aug 23, 2020·Journal of Minimally Invasive Gynecology·Rebecca StoneErica Weston
Dec 22, 2020·The Annals of Thoracic Surgery·Howard L CorwinPierre Tibi

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