Effect of recombinant interleukin-5, interleukin-3, and eotaxin on apoptosis in eosinophilic granulocytes

Bulletin of Experimental Biology and Medicine
N V RyazantsevaN Yu Chasovskikh

Abstract

We studied in vitro effects of recombinant interleukin-5, interleukin-3, and eotaxin on programmed death of eosinophils from healthy donors and patients with non-Hodgkin's lymphomas associated with severe blood eosinophilia. Interleukin-5 and eotaxin produced the most potent antiapoptotic effect on eosinophils from healthy donors. In patients with non-Hodgkin's lymphomas, spontaneous apoptosis in eosinophilic leukocytes was low and remained unchanged during incubation with recombinant proteins.

References

Mar 29, 2002·American Journal of Respiratory Cell and Molecular Biology·James G Zangrilli
Jun 15, 2010·Tsitologiia·A V ShakhbazovM P Potapnev

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Citations

Jan 15, 2011·Bulletin of Experimental Biology and Medicine·N V RyazantsevaA N Baikov
Jan 9, 2010·Expert Opinion on Therapeutic Targets·Brian M Nolen, Anna E Lokshin

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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