Effect of Red Ginseng on Genotoxicity and Health-Related Quality of Life after Adjuvant Chemotherapy in Patients with Epithelial Ovarian Cancer: A Randomized, Double Blind, Placebo-Controlled Trial

Nutrients
Hee Seung KimYong Sang Song

Abstract

We evaluated the effect of red ginseng on toxicity, health-related quality of life (HRQL) and survival after adjuvant chemotherapy in patients with epithelial ovarian cancer (EOC). A total of 30 patients with EOC were randomly assigned to placebo (n = 15) and red ginseng groups (n = 15). All patients took placebo or red ginseng (3000 mg/day) for three months. Then, we compared changes of genotoxicity, HRQL and survival between the two groups. As a result, red ginseng reduced micronuclei yield in comparison with placebo despite no difference of binucleated cells index. Although red ginseng increased serum levels of alanine aminotransferase and aspartate aminotransferase significantly, they were within the normal value. Moreover, there were no differences in adverse events between placebo and red ginseng groups. In terms of HRQL, red ginseng was associated with improved emotional functioning and decreased symptoms of fatigue, nausea and vomiting, and dyspnea, reduced anxiety and interference affecting life and improved daytime somnolence. However, there was no effect of red ginseng on prognosis of EOC. Conclusively, red ginseng may be safe and effective to reduce genotoxicity and improve HRQL despite no benefit of survival in pat...Continue Reading

References

Nov 26, 1999·Biochemical Pharmacology·A S AtteleC S Yuan
Aug 7, 2002·Biochemical and Biophysical Research Communications·Sunoh KimHyewhon Rhim
Feb 6, 2003·The American Journal of Chinese Medicine·Sung Ock SuhMin Young Cho
May 8, 2004·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Y H YunK West
Jun 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lorna ButlerAndrea Bezjak
Jan 19, 2005·Journal of Pharmacological Sciences·Ji Hyun KimInsop Shim
Feb 1, 2005·Sleep Medicine·Ron D HaysKaren L Spritzer
Mar 1, 2005·Journal of Pain and Symptom Management·Young Ho YunCharles S Cleeland
Jun 16, 2005·Mutagenesis·Tung-Kwang LeeLarry J Dobbs
Apr 21, 2006·Basic & Clinical Pharmacology & Toxicology·Zhenhua WangRongliang Zheng
Aug 3, 2006·Journal of Clinical Pharmacy and Therapeutics·Jong-Hoon KimSung-Jae Lee
Dec 22, 2006·The Journal of Nutrition·Lorne J Hofseth, Michael J Wargovich
Jun 5, 2007·Nature Protocols·Michael Fenech
Oct 2, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Qiu Hua ZhangJing Yu Yang
Feb 5, 2008·Journal of Ethnopharmacology·V Badireenath Konkimalla, Thomas Efferth
May 6, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Debra L BartonCharles L Loprinzi
Sep 18, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Dominique KoensgenUNKNOWN Nord-Ostdeutschen Gesellschaft für Gynäkologische Onkologie (NOGGO) working group "Quality of life"
Jan 19, 2010·Chinese Journal of Integrative Medicine·Yan-zhi ChenPing-ping Li
Dec 18, 2010·Mutagenesis·Ilse DecordierMicheline Kirsch-Volders
Jan 25, 2011·Natural Product Reports·Lian-Wen QiChun-Su Yuan
May 1, 2013·Journal of Pain and Symptom Management·Jung Hye KwonEduardo Bruera
May 30, 2013·Journal of Ginseng Research·In-Ho Baeg, Seung-Ho So
Jul 16, 2013·Journal of the National Cancer Institute·Debra L BartonCharles L Loprinzi
May 30, 2014·The American Journal of Chinese Medicine·Chao-Yun WangChun-Hua Wang
Jun 1, 2014·The Proceedings of the Nutrition Society·Antonis VlassopoulosEmilie Combet
Jan 15, 2015·Annals of Surgical Oncology·Francesco PlottiRoberto Angioli
Apr 16, 2015·Integrative Cancer Therapies·Sriram YennurajalingamEduardo Bruera
Sep 28, 2016·Recent Patents on Inflammation & Allergy Drug Discovery·Nassia Kioukia-FougiaChristina Tsitsimpikou
Apr 7, 2017·Journal of Gynecologic Oncology·Dong Hoon SuhJae Weon Kim

❮ Previous
Next ❯

Citations

Sep 25, 2018·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Eran Ben-AryeOfer Lavie
Jan 29, 2019·The American Journal of Hospice & Palliative Care·Mellar P Davis, Bertrand Behm
Oct 4, 2019·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Hyunyoung LeeKwang-Hyeon Liu
Feb 9, 2018·Oncotarget·Islam M D SodrulHongxiang Sun
Jul 22, 2020·Nutrition and Cancer·Mehdi SadeghianAhmad Zare Javid
Sep 8, 2019·Archives of Pharmacal Research·Min-Koo Choi, Im-Sook Song
Apr 19, 2020·Japanese Journal of Clinical Oncology·Kun-Ming RauRuey-Kuen Hsieh
Nov 22, 2018·Frontiers in Pharmacology·Qing-Yu ZhangLing-Dong Kong
Jul 26, 2019·Journal of the American College of Nutrition·Shareen BangaSawinder Kaur
Mar 16, 2019·Journal of Clinical Medicine·Amna ParveenSun Yeou Kim
Feb 18, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Franz OeschThomas Efferth

❮ Previous
Next ❯

Methods Mentioned

BETA
density gradient centrifugation

Software Mentioned

SPSS
IMSTAR
Power Analysis and Sample Size ( PASS )

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research
P Marquis
International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
J K KaukuaA M Rissanen
© 2021 Meta ULC. All rights reserved