PMID: 8957711Jan 1, 1996Paper

Effect of reduced protein adsorption on platelet adhesion at the phospholipid polymer surfaces

Journal of Biomaterials Science. Polymer Edition
Y IwasakiN Nakabayashi

Abstract

We prepared polymers having a phospholipid polar group, poly [omega-methacryloyloxyalkyl phosphorylcholine (MAPC)-co-n-butyl methacrylate(BMA)], as new biomedical materials and evaluated their blood compatibility with attention to protein adsorption and platelet adhesion. The total amount of proteins adsorbed on the polymer surface from human plasma was determined, and the distribution of adsorbed proteins on the plasma-contacting surface was analyzed. The amount of proteins adsorbed on every poly (MAPC-co-BMA) was small compared with that observed on polymers without the phospholipid polar group. However, there was no significant difference in the amount of adsorbed proteins on the poly(MAPC-co-BMA) even when the methylene chain length between the phospholipid polar group and the backbone in the MAPC moiety was altered. Platelet adhesion on the polymer surface from a platelet suspension in a buffered solution was evaluated with and without plasma treatment on the surface. When a rabbit platelet suspension was brought into contact with the poly(BMA) surface after treatment with plasma, many platelets adhered and aggregated. However, a reduced amount of platelet adhered on the poly(BMA) was found in the case of direct contact wi...Continue Reading

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Citations

Oct 16, 2004·Biomaterials·Tomohiro KonnoYoshihiro Ito
Jul 9, 1999·Journal of Biomedical Materials Research·Y IwasakiK Ishihara
Sep 19, 1997·Journal of Biomedical Materials Research·Y IwasakiN Nakabayashi
Sep 2, 1998·Journal of Biomaterials Science. Polymer Edition·Y IwasakiH B Lee
Mar 27, 2001·Journal of Biomaterials Science. Polymer Edition·N M LambaS L Cooper
Apr 1, 2005·Journal of Biomedical Materials Research. Part a·Jasmine D PatelJames M Anderson
Apr 26, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Nicoleta DumitrascuGabriela Borcia
Jul 2, 2009·Journal of Biomedical Materials Research. Part a·Qiang WangRichard T Schoephoerster
Dec 11, 1999·Journal of Biomaterials Science. Polymer Edition·D LeckbandA Halperin
Feb 22, 2005·Analytical and Bioanalytical Chemistry·Yasuhiko Iwasaki, Kazuhiko Ishihara
Sep 30, 2010·Biomedical Materials·Aya SaitoKazuhiko Ishihara
Aug 15, 2017·Journal of Biomaterials Science. Polymer Edition·Masako TanakaYasuhiko Iwasaki
May 7, 2014·Biomaterials Science·Yukichi HoriguchiYukio Nagasaki
Jun 5, 1999·Journal of Biomaterials Science. Polymer Edition·Y IwasakiK Ishihara

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