Effect of regional and systemic fluorinated pyrimidine chemotherapy on quality of life in colorectal liver metastasis patients

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
S EarlamT G Allen-Mersh

Abstract

Since systemic and regional (HAI) fluorinated pyrimidine chemotherapies offer similar survival benefit in treatment of colorectal liver metastases (CLM), we sought to identify their impact on quality of life (QoL), which might be a useful indicator of treatment preference. We compared QoL in 135 CLM patients managed by symptom control (n = 49 patients), systemic fluorouracil (5FU)/folinic acid (n = 35), or hepatic arterial floxuridine (FUDR) (n = 51). Full blood count and liver function tests, World Health Organization (WHO) toxicity criteria, and QoL (Rotterdam Symptom Checklist [RSC], the Sickness Impact Profile [SIP], and the Hospital Anxiety and Depression scale [HAD]) were measured monthly in all patients. The HAD anxiety score was significantly increased in symptom control compared with chemotherapy patients 1 month after randomization. There was a significant increase in RSC physical score (repeated measures, P = .05), and in scores for sore mouth (P < .01), dry mouth (P < .01), and tingling hands and feet (P < .01) in systemic chemotherapy compared with symptom control patients. Significant QoL differences (repeated measures and Mann-Whitney U [MWU]) between HAI and symptom control patients were not detected. Systemic c...Continue Reading

Citations

Dec 10, 2002·Cancer Biotherapy & Radiopharmaceuticals·Bohuslav MelicharJaroslav Cerman
Jul 11, 2019·The Cochrane Database of Systematic Reviews·Malgorzata M BalaJos Kleijnen
May 23, 2008·The British Journal of Surgery·D DasguptaJ P A Lodge
Nov 17, 1998·Journal of the Royal Society of Medicine·T G Allen-MershM Davies
Jul 28, 2012·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Bohuslav Melichar
Dec 9, 2014·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Bohuslav MelicharAntonin Krajina

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