PMID: 8955400Dec 1, 1996Paper

Effect of regulatory protein levels on utilization of starch by Bacteroides thetaiotaomicron

Journal of Bacteriology
J N D'Elia, A A Salyers

Abstract

Bacteroides thetaiotaomicron, a gram-negative obligate anaerobe, appears to utilize starch by first binding the polymer to its surface and then translocating it into the periplasmic space. Several genes that encode enzymes or outer membrane proteins involved in starch utilization have been identified. These have been called sus genes, for starch utilization system. Previous studies have shown that sus structural genes are regulated at the transcriptional level and their expression is induced by maltose. We report here the identification and characterization of a gene, susR, which appears to be responsible for maltose-dependent regulation of the sus structural genes. The deduced amino acid sequence of SusR protein had a helix-turn-helix motif at its carboxy-terminal end, and this region had highest sequence similarity to the corresponding regions of known transcriptional activators. A disruption in susR eliminated the expression of all known sus structural genes, as expected if susR encoded an activator of sus gene expression. The expression of susR itself was not affected by the growth substrate and was not autoregulated, suggesting that binding of SusR to maltose might be the step that activates SusR. Three susR-controlled str...Continue Reading

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Citations

May 31, 2013·Glycobiology·Angela MarcobalJustin L Sonnenburg
Feb 1, 2017·Journal of Bacteriology·Julie M GrondinHarry Brumer
Mar 23, 2017·The ISME Journal·Greta ReintjesRudolf Amann
May 1, 2009·The Journal of Biological Chemistry·Eric C MartensJeffrey I Gordon
May 8, 2013·Molecular Microbiology·Theresa E RogersEric C Martens
May 4, 2016·Cellular and Molecular Life Sciences : CMLS·Matthew H FoleyNicole M Koropatkin
Mar 15, 2018·Nature Communications·Benjamin PluvinageD Wade Abbott
Jul 25, 2019·Applied Microbiology and Biotechnology·Ravindra Pal Singh
Jun 11, 2002·Annual Review of Nutrition·Lora V HooperJeffrey I Gordon
Aug 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jian Xu, Jeffrey I Gordon
Oct 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Tomomi KuwaharaYoshinari Ohnishi
Jun 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Erica D SonnenburgJeffrey I Gordon
Jun 26, 2009·The Journal of Biological Chemistry·Eric C MartensJeffrey I Gordon
Aug 25, 2016·BMC Genomics·Anne AbotVéronique Anton Leberre
Mar 13, 2018·Molecular Microbiology·Matthew H FoleyNicole M Koropatkin
Aug 12, 2020·Critical Reviews in Food Science and Nutrition·Meng YeWei Liu
Nov 15, 2002·Proceedings of the National Academy of Sciences of the United States of America·Thaddeus S StappenbeckJeffrey I Gordon
Jan 12, 2011·Molecular Microbiology·Dylan DoddIsaac K O Cann
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Jun 11, 2020·Glycobiology·Haley A Brown, Nicole M Koropatkin
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Nov 14, 2020·Environmental Microbiology·Jonathon A BriggsHarry Brumer
Feb 6, 2021·Biological Chemistry·Daniel RyanAlexander J Westermann

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