Effect of regulatory warnings on antipsychotic prescription rates among elderly patients with dementia: a population-based time-series analysis.

CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne
Elmira ValiyevaGeoffrey M Anderson

Abstract

Three warnings of serious adverse events associated with the use of atypical antipsychotic drugs among elderly patients with dementia were sent to health care professionals in Canada. We assessed the impact of these warnings on prescription rates of antipsychotic drugs in this patient population. We used prescription drug claims data from Ontario to calculate prescription rates of atypical and conventional antipsychotic drugs among elderly patients with dementia from May 1, 2000, to Feb. 28, 2007. We performed a time-series analysis to estimate the effect of each warning on rates of antipsychotic drug use. Before the first warning, growth in the use of atypical antipsychotics was responsible for an increasing rate of overall antipsychotic use. Each warning was associated with a small relative decrease in the predicted growth in the use of atypical antipsychotic drugs: a 5.0% decrease after the first warning, 4.9% after the second and 3.2% after the third (each p < 0.05). The overall prescription rate of antipsychotic drugs among patients with dementia increased by 20%, from 1512 per 100 000 elderly patients in September 2002, the month before the first warning, to 1813 per 100 000 in February 2007, 20 months after the last warn...Continue Reading

References

Dec 21, 2000·JAMA : the Journal of the American Medical Association·W SmalleyW A Ray
Sep 5, 2001·Quality in Health Care : QHC·A Edwards, G Elwyn
Aug 14, 2002·Journal of Clinical Pharmacy and Therapeutics·A K WagnerD Ross-Degnan
Apr 21, 2004·International Journal of Technology Assessment in Health Care·Craig R RamsayRuth E Thomas
Apr 28, 2004·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Eric Wooltorton
May 25, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Stephen A Goldman
Sep 24, 2004·Pharmacoepidemiology and Drug Safety·Deborah ShatinDavid Graham
Jan 26, 2005·BMJ : British Medical Journal·Sudeep S GillMuhammad Mamdani
May 26, 2005·JAMA : the Journal of the American Medical Association·Bridget M Kuehn
Oct 20, 2005·JAMA : the Journal of the American Medical Association·Lon S SchneiderPhilip Insel
Oct 20, 2005·JAMA : the Journal of the American Medical Association·Peter V Rabins, Constantine G Lyketsos
Dec 2, 2005·The New England Journal of Medicine·Philip S WangM Alan Brookhart
Jul 13, 2006·Health Affairs·Aaron S KesselheimJerry Avorn
Oct 19, 2006·JAMA : the Journal of the American Medical Association·Paul J HauptmanThomas E Burroughs
May 9, 2007·Health Affairs·Jennifer M PolinskiMichael A Fischer
Jun 6, 2007·Annals of Internal Medicine·Sudeep S GillPaula A Rochon
Apr 9, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Laurence Y KatzJitender Sareen

❮ Previous
Next ❯

Citations

Mar 19, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jana SchulzeFalk Hoffmann
Feb 27, 2009·International Psychogeriatrics·Laura H P EggermontErik J A Scherder
Nov 15, 2011·International Psychogeriatrics·Guk-Hee Suh
Jun 21, 2011·Qualitative Health Research·Ester Carolina Apesoa-VaranoLadson Hinton
Aug 30, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Laurence Y Katz
Apr 20, 2011·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Paul C HébertStuart MacLeod
May 27, 2014·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Gianluca TrifiróEdoardo Spina
Apr 27, 2010·Harvard Review of Psychiatry·Lama M ChahineZeina Chemali
Nov 10, 2009·International Clinical Psychopharmacology·Gianluca TrifiròFabio Samani
May 31, 2012·Drugs & Aging·Anne StephensonPaula Rochon
Feb 22, 2011·Revista de calidad asistencial : organo de la Sociedad Española de Calidad Asistencial·J L Catalán-Arlandis
Nov 30, 2011·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Lorraine L LipscombePaula A Rochon
Dec 22, 2009·Gaceta sanitaria·Eduardo Carracedo-Martínez, Agustín Pía-Morandeira
Oct 13, 2009·Medicina clínica·Eduardo Carracedo Martínez, Agustín Pía-Morandeira
Nov 4, 2015·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Akshya VasudevMuhammad Mamdani
Oct 28, 2016·Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists·Chia-Lun KuoChing-Heng Lin
Apr 10, 2009·Pharmacoepidemiology and Drug Safety·Elisabetta PoluzziFabrizio De Ponti
Jul 2, 2011·Journal of the American Geriatrics Society·Leonor LaredoAntonio Portolés
Jan 12, 2012·Pharmacoepidemiology and Drug Safety·Eduardo Carracedo-MartínezAdolfo Figueiras
May 14, 2011·British Journal of Clinical Pharmacology·E Fatma SenUNKNOWN TEDDY European Network of Excellence
Mar 13, 2014·Pharmacoepidemiology and Drug Safety·Inna GridchynaYola Moride
Oct 16, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Adeline GalliniVirginie Gardette
Sep 28, 2015·The International Journal of Risk & Safety in Medicine·Joel Lexchin
Aug 11, 2015·Clinical Therapeutics·Sara SoaresMaria Teresa Herdeiro
Jan 29, 2013·Expert Opinion on Pharmacotherapy·Peter Paul De DeynDebby Van Dam
Feb 3, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Carlotta FranchiAlessandro Nobili
May 31, 2016·International Journal of Geriatric Psychiatry·Alice BreiningArmelle Leperre-Desplanques
Jun 1, 2016·Drugs & Aging·Andrea IaboniAlastair J Flint
Jun 5, 2016·Fundamental & Clinical Pharmacology·Maria T HerdeiroAdolfo Figueiras
Aug 29, 2016·Journal of Alzheimer's Disease : JAD·Johanne Købstrup ZakariasGunhild Waldemar
Nov 4, 2008·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Gianluca TrifiròGiovanni Gambassi
Feb 18, 2017·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Andrea Iaboni, Mark J Rapoport
Feb 18, 2017·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Julia KirkhamDallas Seitz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Related Papers

The New England Journal of Medicine
Lon S SchneiderCATIE-AD Study Group
CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne
Sebastian SchneeweissPhilip S Wang
JAMA : the Journal of the American Medical Association
Pierre N Tariot
© 2022 Meta ULC. All rights reserved