Effect of reinforcement particle size on in vitro behavior of beta-tricalcium phosphate-reinforced high-density polyethylene: a novel orthopedic composite

Journal of Biomedical Materials Research. Part a
S Sh HomaeigoharA Yari Sadi

Abstract

Beta-tricalcium phosphate-reinforced high-density polyethylene (beta-TCP/HDPE) is a new biomaterial, which was made to simulate bone composition and study its capacity to act like bony tissues. This material was produced by replacing mineral component and collagen soft tissue of bone with beta-TCP and HDPE, respectively. The biocompatibility of composite samples with different volume fractions of TCP (20, 30, and 40 vol %) and two different particle sizes (80-100 and 120-140 mesh size) was examined in vitro using the osteoblast cell line G-292 by proliferation, alkaline phosphatase (ALP) production, and cell adhesion assays. Cell-material interaction on the surface of the composites was observed by scanning electron microscopy (SEM). The effect of beta-TCP particle size on behavior of the osteoblast cell line was compared between two groups of the composite samples containing smaller and larger reinforcement particle sizes as well as with those of a negative control. In general, results showed that the composite samples containing larger particles supported a higher rate of proliferation and ALP production by osteoblast cells after 3, 7, and 14 days of incubation compared to the composite samples with smaller particle size and ...Continue Reading

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Citations

Jun 30, 2007·Journal of Biomedical Materials Research. Part a·J RománM Vallet-Regí
Feb 4, 2010·Journal of Biomedical Materials Research. Part a·Neda AboudzadehMehdi Farokhi
Sep 30, 2010·Journal of Biomedical Materials Research. Part a·M A ShokrgozarJ Radfar
Jul 10, 2007·Journal of Biomedical Materials Research. Part a·S Sh HomaeigoharA Yari Sadi
Apr 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Shahin HomaeigoharAldo R Boccaccini

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