Effect of relative humidity during tabletting on matrix formation of hydrocolloids: densification behavior of cellulose ethers

Pharmaceutical Development and Technology
K M Picker, J B Mielck

Abstract

The aim of this research was to investigate the elastic-plastic deformation behavior of the cellulose ethers hydroxypropylmethylcellulose (HPMC), hydroxyethylmethylcellulose (HEMC), and sodium carboxymethylcellulose (NaCMC) at relative humidities (RH) of 38, 57, and 75% and assess how the release of drugs embedded in such matrices is affected by the inner structure of the tablets formed during tabletting. Sorption and desorption isotherms and glass transition temperature were determined between 32 and 75% RH. The materials were equilibrated at 38, 57, and 75% RH and tabletted to a range of graded maximum relative densities. Pressure-time and displacement-time curves were analyzed by use of the Heckel function and a modified Weibull function (pressure-time only). After equilibration at the different RHs, all materials were in the glassy state. The respective degrees of polymerization had negligible effect on the absolute content of water, the sorption isotherms, and finally the densification behavior. At 38% RH, NaCMC contains the same amount of water as HPMC and HEMC, but deforms less plastically than the latter. This is attributed to tight binding of the water of hydration in the former. With increasing RH, NaCMC becomes only ...Continue Reading

References

Sep 1, 1989·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·A Oksanen, S Nikander
Jan 1, 1997·Journal of Pharmaceutical Sciences·B C Hancock, G Zografi
Aug 1, 1986·Pharmaceutical Research·G Zografi, M J Kontny

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Citations

May 11, 2004·Drug Development and Industrial Pharmacy·Katharina M Picker
Mar 11, 1999·Drug Development and Industrial Pharmacy·K M Picker
Mar 15, 2001·Pharmaceutical Development and Technology·K M Picker

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