PMID: 7336681Sep 1, 1981Paper

Effect of remantadine on the development of toxicoses caused by different strains of influenza virus

Voprosy virusologii
I V Kiseleva

Abstract

The effect of remantadine on the development of viral toxicosis caused in mice by original and remantadine-resistant strains of influenza virus was studied. A definite reduction of the antitoxic effectiveness of remantadine was demonstrated in passages of toxigenic influenza A virus strain in its presence. Prophylactic administration of remantadine protected mice from the development of toxic pulmonary edema and death caused by inoculation of a massive dose of influenza B virus. Passages of influenza B virus in the presence of remantadine produced a strain causing toxicosis in mice the course of which was not affected by remantadine any longer.

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