Effect of "renal-dose" dopamine on renal function following cardiac surgery

Anaesthesia and Intensive Care
P S MylesA M Weeks

Abstract

The efficacy of renal-dose dopamine to improve renal function or reduce renal impairment was studied in 52 patients undergoing elective coronary artery bypass surgery. The patients were prospectively randomised in a double-blind fashion to receive dopamine at 200 micrograms/min (group D) or placebo (group P) from induction for 24 hours. Although dopamine improved haemodynamics, there was no effect on urine output at 4 hours (D = 917, P = 1231 ml: P = 0.066); urine output at 24 hours (D = 3659, P = 3304 ml: P = 0.36); creatinine clearance at 0-4 hours (D = 104, P = 127 ml/min: P = 0.27); creatinine clearance on admission to ICU-4 hours (D = 94.8, P = 83.4 ml/min: P = 0.48); creatinine clearance at 20-24 hours (D = 91.2, P = 107 ml/min: P = 0.48); free-water clearance at 0-4 hours (D = 29.6, P = -59.8 ml/hr: P = 0.069); free-water clearance at 20-24 hours (D = 43.2, P = -48.9 ml/hr: P = 0.55). The incidence of transient renal impairment was similar in both groups (D = 36%, P = 50%: P = 0.65). Our study failed to demonstrate that routine prophylactic renal-dose dopamine is associated with improvement in renal function, or with prevention of transient renal impairment in patients undergoing coronary artery bypass surgery.

References

Jan 1, 1978·Postgraduate Medical Journal·V BorirakchanyavatV Sitprija
Jun 1, 1976·Annals of Internal Medicine·J G BhatD S Baldwin
Sep 1, 1989·Pediatric Research·E GirardinL Paunier
Oct 1, 1988·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S G RostandA D Pacifico
Feb 1, 1974·Archives of Surgery·R M AbelW G Austen
Feb 12, 1972·British Medical Journal·E D YeboahJ L Pead
Apr 1, 1967·Postgraduate Medical Journal·R G Luke, A C Kennedy
Oct 18, 1980·Lancet·I S HendersonA C Kennedy
Jan 1, 1984·Nephron·G GrazianiC Ponticelli

❮ Previous
Next ❯

Citations

Nov 30, 2000·Anesthesiology Clinics of North America·B C Weldon, T G Monk
Nov 30, 2000·Anesthesiology Clinics of North America·P K Schoenwald
May 1, 1998·Annals of Surgery·P W PerdueM J Breslow
Aug 1, 1995·Australian and New Zealand Journal of Medicine·G J MangosJ A Whitworth
Jul 1, 2005·Critical Care : the Official Journal of the Critical Care Forum·Michael GilliesBrian Buxton
Sep 22, 2009·Acta Anaesthesiologica Scandinavica·Bengt RedforsSven-Erik Ricksten
Mar 16, 2004·Journal of Cardiac Surgery·Inbar GatotAzai Apelbom
Sep 18, 2004·Seminars in Cardiothoracic and Vascular Anesthesia·Susan Garwood
Mar 1, 1996·Acta Anaesthesiologica Scandinavica·J BondeN V Olsen
Feb 15, 2008·Critical Care Medicine·Kelly V LiangMargaret M Redfield
Mar 7, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Swen N PiperJoachim Boldt
Feb 3, 2007·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Samar TahaAnis Baraka
Jun 4, 2010·Drugs·Ulrich KunzendorfAnja Haase-Fielitz
May 29, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Zoltán H Endre, John W Pickering
Jul 29, 1998·Circulation·P van de BorneV K Somers
Sep 13, 2013·The Cochrane Database of Systematic Reviews·Mathew ZachariasNiamh P Conlon
Feb 7, 2019·Journal of Clinical Monitoring and Computing·Kyle M BurkJoseph A Orr
Mar 17, 1999·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·A ManchéW Busuttil
Jul 5, 2016·Critical Care : the Official Journal of the Critical Care Forum·Jason B O'NealFrederic T Billings
Jul 10, 2002·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Edwin B C WooTimothy L Hooper
Mar 17, 2001·Anaesthesia·R M Orme, M Williams
Oct 23, 2003·Anesthesia and Analgesia·Olivia V CarcoanaSusan Garwood
Jan 27, 2004·Anesthesia and Analgesia·Yves A Debaveye, Greet H Van den Berghe
Apr 5, 2001·International Anesthesiology Clinics·A D Friedrich
May 31, 2001·Critical Care Medicine·R N Sladen
Oct 5, 2006·Current Opinion in Anaesthesiology·J Byers, R N Sladen
Aug 16, 2001·Critical Care Medicine·J A Kellum, J M Decker
Nov 16, 2004·São Paulo Medical Journal = Revista Paulista De Medicina·Cláudia Nathalie PereiraJosé Luiz Gomes do Amaral
Jan 24, 2015·Journal of Applied Physiology·Heather EdgellMichael K Stickland
Jan 18, 2015·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Megan A RechUNKNOWN Critical Care Pharmacotherapy Literature Update Group
Mar 4, 2008·The International Journal of Artificial Organs·M SchetzJ A Kellum

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.