PMID: 8584502Aug 1, 1995Paper

Effect of renal ischaemia on organic compound transport in rabbit kidney proximal tubule

Pharmacology & Toxicology
Y K KimS H Lee

Abstract

This study was carried out to determine the effect of renal ischaemia on transport systems for organic compounds in the rabbit kidney proximal tubule. Ischaemia for 30 or 60 min. induced glucosuria and phosphaturia, which was accompanied by polyuria and natriuresis. The Na(+)-dependent uptake of glucose, succinate and L-glutamate by brush-border membrane vesicles was not altered by 30 or 60 min. of ischaemia, while the H+/tetraethylammonium antiport was significantly inhibited after 30 min. of ischaemia. When the duration of ischaemia was extended to 120 min. the uptake of glucose and succinate by brush-border membrane vesicles was also significantly attenuated, but the L-glutamate uptake was not altered. The uptake of glucose, succinate and L-glutamate by basolateral membrane vesicles was not impaired even with 120 min. of ischaemia, suggesting that transport systems for organic compounds in the brush-border membrane are more sensitive to ischaemia than those in the basolateral membrane. Ouabain-sensitive oxygen consumption in renal cortical slices was not depressed by 60 min. of ischaemia. When kidneys were reperfused for 60 min. following 60 min. of ischaemia, the Na(+)-glucose and Na(+)-succinate cotransport and the H+/tetr...Continue Reading

References

Sep 1, 1976·Journal of Toxicology and Environmental Health·W O Berndt
Jan 1, 1992·Canadian Journal of Physiology and Pharmacology·Y K KimS H Lee
Dec 1, 1989·Journal of Cardiovascular Pharmacology·M SilvermanJ B Puschett
Dec 1, 1988·The Journal of Urology·W S McDougal
Sep 1, 1987·The Journal of Clinical Investigation·B A Molitoris, R Kinne
May 1, 1950·Proceedings of the Society for Experimental Biology and Medicine·G E SCHREINER
May 1, 1945·The Journal of Clinical Investigation·H W SmithM Graber

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Citations

Apr 24, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gabriela CouxLaura Trumper
Sep 30, 2014·Physiological Reports·Pamella A MalagrinoAlexandre C Pereira
Aug 28, 2009·Archives of Biochemistry and Biophysics·Natália Assaife-LopesCelso Caruso-Neves

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