Effect of renin on brain arterioles and cerebral blood flow in rabbits

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
R L HaberlK Hermann

Abstract

There is evidence of an intrinsic renin-angiotensin system in the brain. The goal of the study was to determine whether stimulation of endogenous angiotensin production by applying renin to the brain surface has an effect on pial arteriolar caliber and CBF. Pial vessel diameters were measured through a closed cranial window in anesthetized rabbits. Percent changes of blood flow in the cortical area under the cranial window were simultaneously measured by laser-Doppler flowmetry. Topical application of 0.01-0.1 U/ml renin induced maximum dilation of 18.9 +/- 4% (mean +/- SD) of pial arterioles within 2 min. Arteriolar calibers thereafter decreased slowly. Flow gradually increased to peak at 38 +/- 15% 50 min after renin application. Angiotensin I levels in jugular blood, as measured by radioimmunoassay, increased to a peak 40 min after topical renin application. Angiotensin II levels in jugular blood and both angiotensin I and II levels in blood samples from the femoral artery did not change. Diameter and flow changes were inhibited by intravenous pretreatment with the converting enzyme blocker captopril (10 mg/kg body wt i.v.). Captopril did not affect the vasodilation and flow increase in response to hypercapnia. Topically app...Continue Reading

References

Aug 1, 1977·Circulation Research·I A Reid
Mar 1, 1979·Acta Physiologica Scandinavica·L EdvinssonC Owman
May 1, 1978·Circulation Research·D Ganten
Sep 1, 1978·Stroke; a Journal of Cerebral Circulation·E P WeiJ L Patterson
May 1, 1975·Stroke; a Journal of Cerebral Circulation·J E LevasseurJ L Patterson
Sep 1, 1992·Brain Research. Brain Research Reviews·J W Wright, J W Harding
Mar 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K TamakiJ Ogata
May 1, 1992·Endocrine Reviews·J M Saavedra
Mar 1, 1991·Hypertension·K R Lynch, M J Peach
Oct 19, 1987·Life Sciences·R B MoffettA Husain
Apr 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·E T WhalleyR H Lye
Jul 11, 1988·The American Journal of Physiology·C A SurmaczG E Mortimore
Aug 1, 1988·Journal of Neurochemistry·K HermannM K Raizada
Apr 28, 1987·Brain Research·H ImbodenD Felix
Jan 1, 1983·Annual Review of Physiology·W M Pardridge
Oct 5, 1981·Brain Research·A HusainR C Speth
Jul 1, 1994·Stroke; a Journal of Cerebral Circulation·R L Haberl

❮ Previous
Next ❯

Citations

Jun 11, 2016·Journal of Neurosurgery·Christoph J GriessenauerMohammadali M Shoja
Jan 21, 2017·Journal of Neurosurgery·Christoph J GriessenauerMohammadali M Shoja
Jan 29, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Mohammadali M ShojaAaron A Cohen-Gadol
Nov 5, 2005·Stroke; a Journal of Cerebral Circulation·Jean-Martin VincentJean-Marc Chillon

❮ Previous
Next ❯

Software Mentioned

ASYST

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.