Effect of repeated electroconvulsive treatment on regional concentrations of tachykinins, neurotensin, vasoactive intestinal polypeptide, neuropeptide Y, and galanin in rat brain.

Journal of Neuroscience Research
C StenforsA A Mathé

Abstract

The effects of single and repeated electroconvulsive treatments (ECTs) on brain regional distribution of substance P (SP), neurokinin A (NKA), neurotensin (NT), neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), and galanin (GAL) were studied in the rat. Rats were divided into four groups receiving one of the following treatments: one ECT, one sham ECT, six ECTs, or six sham ECTs. After sacrifice by focused microwave irradiation, brains were dissected into frontal cortex, striatum, occipital cortex, hippocampus, hypothalamus, and pituitary sections. Peptides were extracted by boiling the tissues in 1 mol/l acetic acid and measured in extract aliquots by specific radioimmunoassays. Marked regional differences (P = .0005) were found for each of the peptides measured. The highest concentrations of SP and NKA were found in the hypothalamus and, in descending order, in striatum, pituitary, frontal cortex, occipital cortex, and hippocampus. For NT, the highest level was found in the hypothalamus and, in descending order, in pituitary, striatum, hippocampus, frontal cortex, and occipital cortex. The highest VIP concentrations were measured in frontal and occipital cortex, followed by pituitary, hypothalamus, striatum, and ...Continue Reading

References

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Citations

Jun 1, 1990·Journal of Neuroscience Research·A A MathéE Theodorsson
Feb 19, 2005·Psychopharmacology·Valeriy SergeyevTomas Hökfelt
Mar 1, 1995·Pharmacology & Therapeutics·J G WettsteinJ L Junien
Sep 1, 1992·Progress in Neuro-psychopharmacology & Biological Psychiatry·C StenforsA A Mathé
Jan 1, 1994·Progress in Neuro-psychopharmacology & Biological Psychiatry·C StenforsE Theodorsson
Jan 1, 1994·Progress in Neurobiology·G Sperk
Mar 31, 1999·Peptides·O RugarnC Stenfors
Dec 15, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·G G NomikosA A Mathé
Oct 7, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hagit CohenAleksander A Mathé
Jul 22, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Astrid BjørnebekkStefan Brené
Jul 1, 1992·Journal of Neurochemistry·P S WiddowsonA E Halaris
Oct 15, 2011·Expert Opinion on Therapeutic Targets·Gang WuAleksander A Mathé
Oct 27, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Katharina DomschkeBernhard T Baune
May 6, 2008·European Psychiatry : the Journal of the Association of European Psychiatrists·Georg Nikisch, Aleksander A Mathé
Dec 24, 2003·Alcoholism, Clinical and Experimental Research·Craig J Slawecki, Jennifer Roth
Jan 6, 2009·Annals of the New York Academy of Sciences·Annika Thorsell

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