Effect of Repeated Glucagon Doses on Hepatic Glycogen in Type 1 Diabetes: Implications for a Bihormonal Closed-Loop System

Diabetes Care
Jessica CastleW Kenneth Ward

Abstract

To evaluate subjects with type 1 diabetes for hepatic glycogen depletion after repeated doses of glucagon, simulating delivery in a bihormonal closed-loop system. Eleven adult subjects with type 1 diabetes participated. Subjects underwent estimation of hepatic glycogen using (13)C MRS. MRS was performed at the following four time points: fasting and after a meal at baseline, and fasting and after a meal after eight doses of subcutaneously administered glucagon at a dose of 2 µg/kg, for a total mean dose of 1,126 µg over 16 h. The primary and secondary end points were, respectively, estimated hepatic glycogen by MRS and incremental area under the glucose curve for a 90-min interval after glucagon administration. In the eight subjects with complete data sets, estimated glycogen stores were similar at baseline and after repeated glucagon doses. In the fasting state, glycogen averaged 21 ± 3 g/L before glucagon administration and 25 ± 4 g/L after glucagon administration (mean ± SEM) (P = NS). In the fed state, glycogen averaged 40 ± 2 g/L before glucagon administration and 34 ± 4 g/L after glucagon administration (P = NS). With the use of an insulin action model, the rise in glucose after the last dose of glucagon was comparable to...Continue Reading

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Citations

Nov 4, 2016·Annals of Biomedical Engineering·Helga BlauwJ Hans DeVries
Mar 13, 2016·The Lancet. Diabetes & Endocrinology·Christian Seerup FrandsenSten Madsbad
Sep 16, 2016·Diabetes, Obesity & Metabolism·Nadine TalebRémi Rabasa-Lhoret
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Jul 29, 2021·Journal of Diabetes Science and Technology·Shylaja SrinivasanEda Cengiz

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Methods Mentioned

BETA
pregnancy test

Clinical Trials Mentioned

NCT01986231

Software Mentioned

MATLAB
Stata

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