Effect of replacement estrogen on insulin-like growth factor-I in postmenopausal women: the Rancho Bernardo Study

The Journal of Clinical Endocrinology and Metabolism
D Goodman-Gruen, E L Barrett-Connor

Abstract

Insulin-like growth factor-I (IGF-I) is associated with protein, carbohydrate, and bone metabolism. Results of previous studies examining the effect of exogenous estrogen on levels of IGF-I have been inconsistent. We examined the cross-sectional association between serum IGF-I levels and hormone replacement therapy (HRT) use in 672 postmenopausal women aged 50 yr and older. The mean age-adjusted IGF-I level was highest in the 415 women who reported never or past HRT use (126.8 micrograms/L), lowest in the 128 women who reported using estrogen alone (99.3 micrograms/L), and intermediate in the 115 women who reported using combination estrogen and progesterone (112.4 micrograms/L). A significant linear decline in mean age-adjusted IGF-I levels by duration of HRT use among all current users was seen. The decrease in serum IGF-I with current use of HRT is not consistent with the fact that both HRT and increased levels of IGF-I have been associated with improved glucose and bone metabolism and lipid profile. Further research is needed to evaluate the effect of the addition of a progestin to oral HRT on IGF-I-induced changes in GH levels.

Citations

Aug 26, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E Barrett-Connor, D Goodman-Gruen
Mar 16, 2007·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Andrew G RenehanAllan Flyvbjerg
Aug 27, 2010·Annals of the New York Academy of Sciences·Michael L Traub, Nanette Santoro
Dec 7, 2007·Fertility and Sterility·Robin H FogleRichard J Paulson
Aug 15, 2014·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Ryusaku MatsumotoYutaka Takahashi
Aug 9, 2001·Endocrine Reviews·W M DrakeS M Shalet

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