Effect of reserpine on the brain uptake of carbon 11 methamphetamine and its N-propagyl derivative, deprenyl

European Journal of Nuclear Medicine
O InoueB Långström

Abstract

The enantiomers of methamphetamine (MAMP) and its N-propagyl derivative, deprenyl, were labelled with carbon 11, and the tissue distribution of these labelled compounds in mice was studied. Both enantiomers of 11C-MAMP rapidly entered into the brain and then disappeared according to a single exponential curve. The enantiomers of 11C-deprenyl were also rapidly distributed to various organs in the same manner. With regard to elimination, however, a stereoselective, long-term retention of radioactivity in the brain, heart and lung, due to its irreversible binding with monoamine oxidase B, was observed for L-11C-deprenyl. In reserpinized mice, the initial brain uptake of both the L and D forms of 11C-MAMP was significantly decreased. On the other hand, the brain uptake of both enantiomers of 11C-deprenyl was slightly increased by pretreatment with reserpine. A significant and non-stereoselective elevation of the lung uptake of 11C-deprenyl was also seen in reserpinized mice. In addition, both the relative tissue distribution and ratios of radioactivity in the brain compared with blood or heart at 1 and 5 min after the injection of 11C-labelled methanol in mice were not changed by reserpine. These results indicate that the transport...Continue Reading

References

Sep 1, 1977·European Journal of Pharmacology·J M Elliott, D W Clark
Sep 1, 1985·Pharmacology, Biochemistry, and Behavior·B J KlauenbergS B Sparber
Sep 23, 1985·Brain Research·C J SchmidtJ W Gibb
Jan 1, 1988·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·K HashimotoT Yamasaki
Jul 8, 1985·Life Sciences·T J DanielsonA Tang
Aug 15, 1985·Biochemical Pharmacology·A LesageJ F Rumigny
Oct 1, 1965·The Journal of Pharmacy and Pharmacology·S ConsoloL Valzelli
Aug 1, 1972·The Biochemical Journal·J CaldwellR T Williams
Mar 15, 1973·Experientia·W M Pardridge, J D Connor
Oct 1, 1969·Biochemical Pharmacology·J M Stolk, R H Rech
Aug 1, 1968·European Journal of Pharmacology·M B Youdim, M Sandler
Jan 1, 1969·European Journal of Pharmacology·E DolfiniS Garattini
Aug 26, 1955·Science·A PLETSCHERB B BRODIE

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Citations

Oct 25, 2003·Annals of Nuclear Medicine·Osamu InoueAntony Gee
Apr 2, 1999·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·N M GillingsO Inoue
Sep 18, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Joanna S FowlerNora D Volkow
Aug 21, 2010·Neurochemical Research·K MagyarE Szöko
Jul 29, 2005·Neurosurgical Focus·James K LiuMarion L Walker

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